ArticleMolecular human reproduction2014
Docetaxel induces moderate ovarian toxicity in mice, primarily affecting granulosa cells of early growing follicles.
Article in Molecular human reproduction, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Molecular mechanisms underlying cyclophosphamide-induced ovarian injury and protective strategies.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats.Open veterinary journal · 2025Article
- Graphene Oxide Nanosheets Induce Mitochondrial Toxicity in Human Ovarian Granulosa Cells: Implications for Female Reproductive Health.International journal of nanomedicine · 2025Article
- The impact ofHuman reproduction open · 2025Review
- Review
- Inhibition of Drp1 orchestrates the responsiveness of breast cancer cells to paclitaxel but insignificantly relieves paclitaxel-related ovarian damage in mice.Scientific reports · 2023Article
- Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions†.Biology of reproduction · 2023Review
- Thyroid hormone triiodothyronine does not protect ovarian reserve from DNA damage induced by X-ray and cisplatin.Journal of assisted reproduction and genetics · 2023Article
- The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence.Frontiers in endocrinology · 2022Review
- The Effects of Negative Elements in Environment and Cancer on Female Reproductive System.Advances in experimental medicine and biology · 2021Article
- Comparative gonadotoxicity of the chemotherapy drugs cisplatin and carboplatin on prepubertal mouse gonads.Molecular human reproduction · 2020Article
- Burning Questions in the Oncofertility Counseling of Young Breast Cancer Patients.Breast cancer : basic and clinical research · 2020Review
- Effects of paclitaxel and cisplatin onArchives of medical science : AMS · 2019Article
- Impact of Taxanes, Endocrine Therapy, and Deleterious GermlineFrontiers in oncology · 2019Article
- Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice.Reproductive biology and endocrinology : RB&E · 2018Article
- Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model.Journal of ovarian research · 2018Article
- A grafted ovarian fragment rescues host fertility after chemotherapy.Molecular human reproduction · 2016Article
- Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice.Molecular human reproduction · 2016Article
- Is there a robust future for research in reproduction?Molecular human reproduction · 2016Article
- Human amniotic epithelial cells inhibit granulosa cell apoptosis induced by chemotherapy and restore the fertility.Stem cell research & therapy · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Advances in cancer therapy have focused attention on the quality of life of cancer survivors. Since infertility is a major concern following chemotherapy, it is important to characterize the drug-specific damage to the reproductive system to help find appropriate protective strategies. This study investigates the damage on neonatal mouse ovary maintained in vitro for 6 days, and exposed for 24 h (on Day 2) to clinically relevant doses of Docetaxel (DOC; low: 0.1 µM, mid: 1 µM, high: 10 µM). Furthermore, the study explores the putative protective action exerted by Tri-iodothyronine (T3; 10(-7) M). At the end of culture, morphological analyses and follicle counts showed that DOC negatively impacts on early growing follicles, decreasing primary follicle number and severely affecting health at the transitional and primary stages. Poor follicle health was mainly due to effects on granulosa cells, indicating that the effects of DOC on oocytes were likely to be secondary to granulosa cell damage. DOC damages growing follicles specifically, with no direct effect on the primordial follicle reserve. Immunostaining and western blotting showed that DOC induces activation of intrinsic, type II apoptosis in ovarian somatic cells; increasing the levels of cleaved caspase 3, cleaved caspase 8, Bax and cleaved poly(ADP-ribose) polymerase, while also inducing movement of cytochrome C from mitochondria into the cytosol. T3 did not prevent the damage induced by the low dose of DOC. These results demonstrated that DOC induces a gonadotoxic effect on the mouse ovary through induction of somatic cell apoptosis, with no evidence of direct effects on the oocyte, and that the damaging effect is not mitigated by T3.
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