ArticleProceedings. Biological sciences2014
Matching the supply of bacterial nutrients to the nutritional demand of the animal host.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
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- Comparative Transcriptomics of Fat Bodies between Symbiotic and Quasi-Aposymbiotic Adult Females ofInternational journal of molecular sciences · 2024Article
- Analysis of gut microbiota of ladybug beetle (Harmonia axyridis) after feeding on different artificial diets.BMC microbiology · 2024Article
- The response of gut and fecal bacterial communities of the European sea bass (Sustainable microbiology · 2024Article
- The impacts of host association and perturbation on symbiont fitness.Symbiosis (Philadelphia, Pa.) · 2024Article
- Host plant-mediated effects onFrontiers in plant science · 2023Article
- Impact of transgenerational host switch on gut bacterial assemblage in generalist pest,Frontiers in microbiology · 2023Article
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- Differential Effects of Sulfur Amino Acid-Restricted and Low-Calorie Diets on Gut Microbiome Profile and Bile Acid Composition in Male C57BL6/J Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Essential Amino Acid Enrichment and Positive Selection Highlight Endosymbiont's Role in a Global Virus-Vectoring Pest.mSystems · 2021Article
- Transcriptomics Reveal the Survival Strategies of Enterococcus mundtii in the Gut of Spodoptera littoralis.Journal of chemical ecology · 2021Article
- Gut Bacterial Diversity in Different Life Cycle Stages ofFrontiers in microbiology · 2021Article
- Ancestral state reconstruction of metabolic pathways across pangenome ensembles.Microbial genomics · 2020Article
- Impact of Facultative Bacteria on the Metabolic Function of an Obligate Insect-Bacterial Symbiosis.mBio · 2020Article
- Dynamics of Insect-Microbiome Interaction Influence Host and Microbial Symbiont.Frontiers in microbiology · 2020Review
- Two Deoxythymidine Triphosphate Synthesis-Related Genes Regulate Obligate Symbiont Density and Reproduction in the WhiteflyFrontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various animals derive nutrients from symbiotic microorganisms with much-reduced genomes, but it is unknown whether, and how, the supply of these nutrients is regulated. Here, we demonstrate that the production of essential amino acids (EAAs) by the bacterium Buchnera aphidicola in the pea aphid Acyrthosiphon pisum is elevated when aphids are reared on diets from which that EAA are omitted, demonstrating that Buchnera scale EAA production to host demand. Quantitative proteomics of bacteriocytes (host cells bearing Buchnera) revealed that these metabolic changes are not accompanied by significant change in Buchnera or host proteins, suggesting that EAA production is regulated post-translationally. Bacteriocytes in aphids reared on diet lacking the EAA methionine had elevated concentrations of both methionine and the precursor cystathionine, indicating that methionine production is promoted by precursor supply and is not subject to feedback inhibition by methionine. Furthermore, methionine production by isolated Buchnera increased with increasing cystathionine concentration. We propose that Buchnera metabolism is poised for EAA production at certain maximal rates, and the realized release rate is determined by precursor supply from the host. The incidence of host regulation of symbiont nutritional function via supply of key nutritional inputs in other symbioses remains to be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.