ArticleProceedings. Biological sciences2014
Heat shock protein expression enhances heat tolerance of reptile embryos.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 62 citations in OpenAlex.
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- Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Early Developmental Decline in HSP Expression Affects Subsequent Response to Transient Heat Exposure.Integrative organismal biology (Oxford, England) · 2025Article
- Article
- The role of body mass in limiting post heat-coma recovery ability in terrestrial ectotherms.Ecology and evolution · 2023Article
- Procyanidin B2 Alleviates Heat-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.International journal of molecular sciences · 2022Article
- Adaptive variation in the upper limits of avian body temperature.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Heritable shifts in redox metabolites during mitochondrial quiescence reprogramme progeny metabolism.Nature metabolism · 2021Article
- Climate warming will increase chances of hybridization and introgression between twoEcology and evolution · 2021Article
- Environmental Thermal Stress Induces Neuronal Cell Death and Developmental Malformations in Reptiles.Integrative organismal biology (Oxford, England) · 2021Article
- Adaptive responses of the embryos of birds and reptiles to spatial and temporal variations in nest temperatures.Proceedings. Biological sciences · 2019Review
- Genomewide identification and analysis of heat-shock proteins 70/110 to reveal their potential functions in Chinese soft-shelled turtleEcology and evolution · 2019Article
- Response of heat shock protein genes of the oriental fruit moth under diapause and thermal stress reveals multiple patterns dependent on the nature of stress exposure.Cell stress & chaperones · 2016Article
- Ecological factors drive natural selection pressure of avian aryl hydrocarbon receptor 1 genotypes.Scientific reports · 2016Article
- Incubation temperature affects the immune function of hatchling soft-shelled turtles, Pelodiscus sinensis.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of heat shock proteins (HSPs) in heat tolerance has been demonstrated in cultured cells and animal tissues, but rarely in whole organisms because of methodological difficulties associated with gene manipulation. By comparing HSP70 expression patterns among representative species of reptiles and birds, and by determining the effect of HSP70 overexpression on embryonic development and hatchling traits, we have identified the role of HSP70 in the heat tolerance of amniote embryos. Consistent with their thermal environment, and high incubation temperatures and heat tolerance, the embryos of birds have higher onset and maximum temperatures for induced HSP70 than do reptiles, and turtles have higher onset and maximum temperatures than do lizards. Interestingly, the trade-off between benefits and costs of HSP70 overexpression occurred between life-history stages: when turtle embryos developed at extreme high temperatures, HSP70 overexpression generated benefits by enhancing embryo heat tolerance and hatching success, but subsequently imposed costs by decreasing heat tolerance of surviving hatchlings. Taken together, the correlative and causal links between HSP70 and heat tolerance provide, to our knowledge, the first unequivocal evidence that HSP70 promotes thermal tolerance of embryos in oviparous amniotes.
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Registered trials
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