ArticleThe journal of physiological sciences : JPS2014
Ghrelin-induced hypophagia is mediated by the β2 adrenergic receptor in chicken.
Article in The journal of physiological sciences : JPS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 59 citations in OpenAlex.
- Central βVeterinary research communications · 2026Article
- Decoding the role of ghrelin and its interactions with central signaling pathways in avian appetite regulation.Veterinary research communications · 2025Review
- Central effects of opioidergic system on food intake in birds and mammals: a review.Veterinary research communications · 2023Review
- Correlation of Histamine Receptors and Adrenergic Receptor in Broilers Appetite.Archives of Razi Institute · 2022Article
- Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken.Archives of Razi Institute · 2021Article
- Interconnection between Adrenergic and Dopaminergic Systems in Feeding Behavior in Neonatal Chicks.Archives of Razi Institute · 2021Article
- Interaction of Central Glutamatergic and Histaminergic Systems on Food Intake Regulation in Layer Chickens.Archives of Razi Institute · 2021Article
- Transcriptome Analysis Reveals Differential Expression of Genes Regulating Hepatic Triglyceride Metabolism in Pekin Ducks During Dietary Threonine Deficiency.Frontiers in genetics · 2019Article
- Modulatory function of NMDA glutamate receptor on MCVeterinary research communications · 2017Article
- Ghrelin enhances food intake and carbohydrate oxidation in a nitric oxide dependent manner.General and comparative endocrinology · 2017Article
- Involvement of histaminergic and noradrenergic receptors in the oxytocin-induced food intake in neonatal meat-type chicks.Veterinary research communications · 2017Article
- Cannabinoid-glutamate interactions in the regulation of food intake in neonatal layer- type chicks: role of glutamate NMDA and AMPA receptors.Veterinary research communications · 2016Article
- Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals.Frontiers in neuroscience · 2016Review
- Role of cannabinoidergic system on food intake in neonatal layer-type chicken.Veterinary research communications · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to examine the effects of intracerebroventricular injection of metoprolol (a β1 adrenergic receptor antagonist), ICI 118,551 (a β2 adrenergic receptor antagonist), and SR 59230R (a β3 adrenergic receptor antagonist) on ghrelin-induced food and water intake by 3-h food-deprived (FD3) cockerels. The chickens were randomly allocated to 4 treatment groups with 8 replicates in each group. A cannula was surgically implanted into the lateral ventricle of the brain. In experiment 1, chickens received the β1 adrenergic receptor antagonist (24 nmol) before injection of the ghrelin (0.6 nmol). In experiment 2, chickens received the β2 adrenergic receptor antagonist (5 nmol) before injection of the ghrelin (0.6 nmol). In experiment 3, birds were injected with ghrelin (0.6 nmol) after the β3 adrenergic receptor antagonist (20 nmol). Cumulative food and water intake were recorded 3-h post injection and analyzed by two-way analysis of variance. According to the results, ghrelin injection reduced food and water intake by broiler cockerels (p≤0.05). The effect of ghrelin on food intake was significantly attenuated by pretreatment with the β2 receptor antagonist (p≤0.05). Furthermore, the β2 receptor antagonist had no effect on water intake induced by ghrelin. Also, pretreatment with the β1 and β3 receptors antagonists had no effect on ghrelin-induced food and water intake. These results suggest that the effect of ghrelin on cumulative food intake by cockerels is mediated via β2 adrenergic receptors.
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