ArticleJournal of natural products2014
Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.
Article in Journal of natural products, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Integrative metabolome and transcriptome analyses reveal the differences in flavonoid and terpenoid synthesis betweenFood science and biotechnology · 2024Article
- Investigation of red clover (Trifolium pratense) isoflavonoid residual complexity by off-line CCS-qHNMR.Fitoterapia · 2022Article
- Quantitative Analysis of Flavonoids inJournal of analytical methods in chemistry · 2021Article
- Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2017Article
- Qualitative and quantitative characterization of secondary metabolites and carbohydrates in Bai-Hu-Tang using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and ultraperformance liquid chromatography coupled with photodiode array detector.Journal of food and drug analysis · 2017Article
- Sweet spot matching: A thin-layer chromatography-based countercurrent solvent system selection strategy.Journal of chromatography. A · 2017Article
- Evolution of Quantitative Measures in NMR: Quantum Mechanical qHNMR Advances Chemical Standardization of a Red Clover (Trifolium pratense) Extract.Journal of natural products · 2017Article
- Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS.Journal of agricultural and food chemistry · 2016Article
- The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls.Advances in nutrition (Bethesda, Md.) · 2016Review
- Holistic Analysis Enhances the Description of Metabolic Complexity in Dietary Natural Products.Advances in nutrition (Bethesda, Md.) · 2016Review
- Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.Chemical research in toxicology · 2015Article
- Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals.Journal of natural products · 2015Article
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Authors and funding
10 authors.
Funding
Abstract
Licorice botanicals are produced from the roots of Glycyrrhiza species (Fabaceae), encompassing metabolites of both plant and rhizobial origin. The composition in both primary and secondary metabolites (1°/2°Ms) reflects the physiologic state of the plant at harvest. Interestingly, the relative abundance of 1°Ms vs 2°Ms in licorice extracts remains undetermined. A centrifugal partition chromatography (CPC) method was developed to purify liquiritin derivatives that represent major bioactive 2°Ms and to concentrate the polar 1°Ms from the crude extract of Glycyrrhiza uralensis. One objective was to determine the purity of the generated reference materials by orthogonal UHPLC-UV/LC-MS and qHNMR analyses. The other objectives were to evaluate the presence of 1°Ms in purified 2°Ms and define their mass balance in a crude botanical extract. Whereas most impurities could be assigned to well-known 1°Ms, p-hydroxybenzylmalonic acid, a new natural tyrosine analogue, was also identified. Additionally, in the most polar fraction, sucrose and proline represented 93% (w/w) of all qHNMR-quantified 1°Ms. Compared to the 2°Ms, accounting for 11.9% by UHPLC-UV, 1°Ms quantified by qHNMR defined an additional 74.8% of G. uralensis extract. The combined orthogonal methods enable the mass balance characterization of licorice extracts and highlight the relevance of 1°Ms, and accompanying metabolites, for botanical quality control.
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