ArticlePloS one2014
Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Prevalence and Molecular Epidemiology of Human Coronaviruses in Africa Prior to the SARS-CoV-2 Outbreak: A Systematic Review.Viruses · 2023Pooled it
- A decade of endemic human coronaviruses: epidemiological patterns and clinical significance in an adult cohort at a tertiary care hospital in Germany.BMC infectious diseases · 2026Article
- Genomic Surveillance of Endemic Human Coronaviruses in Côte d'Ivoire Using Targeted Hybrid-Capture Sequencing.Viruses · 2026Article
- Circulation of Human Coronaviruses in SARS-CoV-2 and Influenza-negative patients with respiratory infections during Ghana's 2021 COVID-19 pandemic.Ghana medical journal · 2026Article
- Serological responses to SARS-CoV-2 in urban and rural Ghana: Antibody waning and implications for long-term population immunity.PloS one · 2026Article
- High prevalence of human coronaviruses in rural and urban Ghana in the post-COVID-19 era.Frontiers in epidemiology · 2026Article
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- External quality assessment of molecular detection and variant typing of SARS-CoV-2 in European expert laboratories in 2023.Journal of clinical microbiology · 2025Article
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- Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017.The Journal of infectious diseases · 2024Observational
- Global Epidemiology and Seasonality of Human Seasonal Coronaviruses: A Systematic Review.Open forum infectious diseases · 2024Article
- Predictors of severity and prolonged hospital stay of viral acute respiratory infections (ARI) among children under five years in Burkina Faso, 2016-2019.BMC infectious diseases · 2024Article
- Characterization and phylogenetic analysis of Iranian SARS-CoV-2 genomes: A phylogenomic study.Health science reports · 2023Article
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- Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins.Journal of biomolecular structure & dynamics · 2022Article
- Coronavirus seasonality, respiratory infections and weather.BMC infectious diseases · 2021Article
- Crystal structures of human coronavirus NL63 main protease at different pH values.Acta crystallographica. Section F, Structural biology communications · 2021Article
- Longitudinal and abattoir-based surveillance of MERS-CoV in camels in Jordan, 2018-2020.Heliyon · 2021Article
- Integrative immunoinformatics paradigm for predicting potential B-cell and T-cell epitopes as viable candidates for subunit vaccine design against COVID-19 virulence.Biomedical journal · 2021Article
- Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study.The Lancet. Microbe · 2021Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory tract infections (ARI) are the leading cause of morbidity and mortality in developing countries, especially in Africa. This study sought to determine whether human coronaviruses (HCoVs) are associated with upper respiratory tract infections among older children and adults in Ghana.
methodsWe conducted a case control study among older children and adults in three rural areas of Ghana using asymptomatic subjects as controls. Nasal/Nasopharyngeal swabs were tested for Middle East respiratory syndrome coronavirus (MERS-CoV), HCoV-22E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 using Reverse Transcriptase Real-Time Polymerase Chain Reaction.
resultsOut of 1,213 subjects recruited, 150 (12.4%) were positive for one or more viruses. Of these, single virus detections occurred in 146 subjects (12.0%) and multiple detections occurred in 4 (0.3%). Compared with control subjects, infections with HCoV-229E (OR = 5.15, 95%CI = 2.24-11.78), HCoV-OC43 (OR = 6.16, 95%CI = 1.77-21.65) and combine HCoVs (OR = 2.36, 95%CI = 1.5 = 3.72) were associated with upper respiratory tract infections. HCoVs were found to be seasonally dependent with significant detections in the harmattan season (mainly HCoV-229E) and wet season (mainly HCoV-NL63). A comparison of the obtained sequences resulted in no differences to sequences already published in GenBank.
conclusionHCoVs could play significant role in causing upper respiratory tract infections among adults and older children in rural areas of Ghana.
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