ArticlePLoS computational biology2014
Human dominant disease genes are enriched in paralogs originating from whole genome duplication.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integration of Large-Scale Genomic Data Sources With Evolutionary History Reveals Novel Genetic Loci for Congenital Heart Disease.Circulation. Genomic and precision medicine · 2019Pooled it
- The Transposable Element Environment of Human Genes Differs According to Their Duplication Status and Essentiality.Genome biology and evolution · 2021Article
- Region-specific expression of young small-scale duplications in the human central nervous system.BMC ecology and evolution · 2021Article
- Review
- Mutations in calmodulin-binding domains of TRPV4/6 channels confer invasive properties to colon adenocarcinoma cells.Channels (Austin, Tex.) · 2020Article
- Sensitivity to gene dosage and gene expression affects genes with copy number variants observed among neuropsychiatric diseases.BMC medical genomics · 2020Article
- OHNOLOGS v2: a comprehensive resource for the genes retained from whole genome duplication in vertebrates.Nucleic acids research · 2020Article
- Modelling of pathogen-host systems using deeper ORF annotations and transcriptomics to inform proteomics analyses.Computational and structural biotechnology journal · 2020Article
- Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases.Computational and structural biotechnology journal · 2020Article
- Chromosome evolution at the origin of the ancestral vertebrate genome.Genome biology · 2018Article
- Selective Constraints on Coding Sequences of Nervous System Genes Are a Major Determinant of Duplicate Gene Retention in Vertebrates.Molecular biology and evolution · 2017Article
- Learning causal networks with latent variables from multivariate information in genomic data.PLoS computational biology · 2017Article
- Article
- Uncovering disease mechanisms through network biology in the era of Next Generation Sequencing.Scientific reports · 2016Article
- Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes.PLoS computational biology · 2015Article
- Fruit flies in biomedical research.Genetics · 2015Article
- Comments on "Human dominant disease genes are enriched in paralogs originating from whole genome duplication".PLoS computational biology · 2014Article
Corrections and comments
- Commented on by
- Comment on
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.