ArticleAdvanced healthcare materials2015
A pharmacokinetic model of a tissue implantable insulin sensor.
Article in Advanced healthcare materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Non-severe hypoglycemia in type 1 diabetes: a randomized crossover trial comparing two quantities of oral carbohydrates at different insulin-induced hypoglycemia ranges.Frontiers in endocrinology · 2023Trial
- A Human Glucoregulatory Model for the Rational Design and Evaluation of Diabetes Therapeutics.ACS pharmacology & translational science · 2026Article
- A Computational Glucoregulatory Model of Liver and Glucagon for the Evaluation of Therapeutics.ACS pharmacology & translational science · 2025Article
- Analysis of Glucose Responsive Glucagon Therapeutics using Computational Models of the Glucoregulatory System.Advanced healthcare materials · 2024Article
- Needle-Shaped Biosensors for Precision Diagnoses: From Benchtop Development to In Vitro and In Vivo Applications.Biosensors · 2024Review
- Transparent Organogels as a Medium for the Light-Induced Conversion from Spiropyran to Merocyanine.Gels (Basel, Switzerland) · 2023Article
- In Silico Investigation of the Clinical Translatability of Competitive Clearance Glucose-Responsive Insulins.ACS pharmacology & translational science · 2023Article
- Rational Design and Efficacy of Glucose-Responsive Insulin Therapeutics and Insulin Delivery Systems by Computation Using Connected Human and Rodent Models.Advanced healthcare materials · 2023Article
- Insulin detection in diabetes mellitus: challenges and new prospects.Nature reviews. Endocrinology · 2023Review
- Single-Walled Carbon Nanotubes as Fluorescent Probes for Monitoring the Self-Assembly and Morphology of Peptide/Polymer Hybrid Hydrogels.Nano letters · 2022Article
- Article
- Diabetes Technology Meeting 2020.Journal of diabetes science and technology · 2021Article
- Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin.Diabetes · 2020Article
- Estimates for energy expenditure in free-living animals using acceleration proxies: A reappraisal.The Journal of animal ecology · 2020Article
- Fluorescent Single-Walled Carbon Nanotubes for Protein Detection.Sensors (Basel, Switzerland) · 2019Review
- Glucose-responsive insulin by molecular and physical design.Nature chemistry · 2017Article
- In Vivo Biosensing: Progress and Perspectives.ACS sensors · 2017Article
- Nitroaromatic detection and infrared communication from wild-type plants using plant nanobionics.Nature materials · 2017Article
- Quantitative Tissue Spectroscopy of Near Infrared Fluorescent Nanosensor Implants.Journal of biomedical nanotechnology · 2016Article
- Protein-targeted corona phase molecular recognition.Nature communications · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
While implantable sensors such as the continuous glucose monitoring system have been widely studied, both experimentally and mathematically, relatively little attention has been applied to the potential of insulin sensors. Such sensors can provide feedback control for insulin infusion systems and pumps and provide platforms for the monitoring of other biomarkers in vivo. In this work, the first pharmacokinetic model of an affinity sensor is developed for insulin operating subcutaneously in the limit of where mass transfer across biological membranes reaches a steady state. Using a physiological, compartmental model for glucose, insulin, and glucagon metabolism, the maximum sensor response and its delay time relative to plasma insulin concentration, are calculated based on sensor geometry, placement, and insulin binding parameters for a sensor localized within adipose tissue. A design relation is derived linking sensor dynamics to insulin time lag and placement within human tissue. The model should find utility in understanding dynamic insulin responses and forms the basis of model predictive control algorithms that incorporate sensor dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.