ReviewSeminars in cell & developmental biology2014
Force and the spindle: mechanical cues in mitotic spindle orientation.
Review in Seminars in cell & developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Aneuploidy in exfoliated buccal cells: mechanisms, methods, and future perspectives.Mutagenesis · 2026Review
- Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephaly.EMBO reports · 2026Article
- Three-dimensional cellular dynamics and mandibular morphogenesis.Frontiers in cell and developmental biology · 2026Article
- Neighbor cells restrain furrowing during Xenopus epithelial cytokinesis.Developmental cell · 2025Article
- Spindle Orientation Regulation Is Governed by Redundant Cortical Mechanosensing and Shape-Sensing Mechanisms.International journal of molecular sciences · 2025Article
- Forcing the code: tension modulates signaling to drive morphogenesis and malignancy.Genes & development · 2025Review
- Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division.Journal of developmental biology · 2022Review
- The Sister Chromatid Division of the Heteromorphic Sex Chromosomes inInternational journal of molecular sciences · 2022Article
- Three-dimensional geometry controls division symmetry in stem cell colonies.Journal of cell science · 2021Article
- The evolution of spindles and their mechanical implications for cancer metastasis.Cell cycle (Georgetown, Tex.) · 2019Article
- Pressure suppresses hepatocellular glycogen synthesis through activating the p53/Pten pathway.Molecular medicine reports · 2019Article
- Division orientation: disentangling shape and mechanical forces.Cell cycle (Georgetown, Tex.) · 2019Review
- Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells.The Journal of cell biology · 2019Article
- Decoupling the Roles of Cell Shape and Mechanical Stress in Orienting and Cueing Epithelial Mitosis.Cell reports · 2019Article
- Article
- Src activation decouples cell division orientation from cell geometry in mammalian cells.Biomaterials · 2018Article
- Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?Bulletin of mathematical biology · 2017Article
- Diverse mitotic functions of the cytoskeletal cross-linking protein Shortstop suggest a role in Dynein/Dynactin activity.Molecular biology of the cell · 2017Article
- E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The mechanical environment of a cell has a profound effect on its behaviour, from dictating cell shape to driving the transcription of specific genes. Recent studies have demonstrated that mechanical forces play a key role in orienting the mitotic spindle, and therefore cell division, in both single cells and tissues. Whilst the molecular machinery that mediates the link between external force and the mitotic spindle remains largely unknown, it is becoming increasingly clear that this is a widely used mechanism which could prove vital for coordinating cell division orientation across tissues in a variety of contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.