Evidence map›Paper›PMID 25079797›Full record

ArticleJournal of Alzheimer's disease : JAD2015

Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer's disease.

Bartholomew J Naughton, F Jason Duncan, Darren A Murrey, Aaron S Meadows, David E Newsom, Nicoleta Stoicea, Peter White, Douglas W Scharre, Douglas M Mccarty, Haiyan Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Meta-Analysis of Transcriptomic Studies of Blood and Six Brain Regions Identifies a Consensus of 15 Cross-Tissue Mechanisms in Alzheimer's Disease and Suggests an Origin of Cross-Study Heterogeneity.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025
    Pooled it
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  6. Omics-derived biological modules reflect metabolic brain changes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bartholomew J NaughtonCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
F Jason DuncanCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Darren A MurreyCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Aaron S MeadowsCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
David E NewsomBiomedical Genomics Core, Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Nicoleta StoiceaDivision of Cognitive Neurology, Forest Hills Center for Alzheimer's Disease, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA Department of Neurology, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA.
Peter WhiteBiomedical Genomics Core, Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA.
Douglas W ScharreDivision of Cognitive Neurology, Forest Hills Center for Alzheimer's Disease, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA Department of Neurology, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA.
Douglas M MccartyCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA.
Haiyan FuCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA.
Nationwide Children's Hospital · USThe Ohio State University · US

Funding

Treating the CNS and Somatic Diseases of MPS IIIB by Systemic Gene DeliveryU01NS069626 · NINDS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI FLANIGAN, KEVIN M, FU, HAIYAN · 2011 to 2014
$4.3M
PATTERNS OF r AAV VECTOR INSERTION ASSOCIATED WITH LIVER TUMORS IN A MOUSE MODELR01CA172713 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FU, HAIYAN · 2013 to 2017
$1.5M
Acquisition of an Illumina Genome Analyzer for The Research InstituteS10RR026942 · NCRR · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WHITE, PETER · 2010 to 2010
$500k
Self-complementary rAAV9 Systemic Gene Delivery Treatment for MPS Type IIIAR21NS081173 · NINDS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI MCCARTY, DOUGLAS M · 2012 to 2013
$394k
NCI NIH HHS R01 CA172713NCI NIH HHS R01CA172713NCRR NIH HHS S10 RR026942NINDS NIH HHS R21 NS081173NINDS NIH HHS R21NS081173NINDS NIH HHS U01 NS069626NINDS NIH HHS U01NS069626
6 · The paper itself

Abstract

To date, little is known regarding the etiology and disease mechanisms of Alzheimer's disease (AD). There is a general urgency for novel approaches to advance AD research. In this study, we analyzed blood RNA from female patients with advanced AD and matched healthy controls using genome-wide gene expression microarrays. Our data showed significant alterations in 3,944 genes (≥2-fold, FDR ≤1%) in AD whole blood, including 2,932 genes that are involved in broad biological functions. Importantly, we observed abnormal transcripts of numerous tissue-specific genes in AD blood involving virtually all tissues, especially the brain. Of altered genes, 157 are known to be essential in neurological functions, such as neuronal plasticity, synaptic transmission and neurogenesis. More importantly, 205 dysregulated genes in AD blood have been linked to neurological disease, including AD/dementia and Parkinson's disease, and 43 are known to be the causative genes of 42 inherited mental retardation and neurodegenerative diseases. The detected transcriptional abnormalities also support robust inflammation, profound extracellular matrix impairments, broad metabolic dysfunction, aberrant oxidative stress, DNA damage, and cell death. While the mechanisms are currently unclear, this study demonstrates strong blood-brain correlations in AD. The blood transcriptional profiles reflect the complex neuropathological status in AD, including neuropathological changes and broad somatic impairments. The majority of genes altered in AD blood have not previously been linked to AD. We believe that blood genome-wide transcriptional profiling may provide a powerful and minimally invasive tool for the identification of novel targets beyond Aβ and tauopathy for AD research.

Indexed as

AgedAlzheimer DiseaseFemaleGene Expression ProfilingHumansMicroarray AnalysisReal-Time Polymerase Chain ReactionAlzheimer's diseaseblood-brain transcriptional associationgenome-wide expression arraysneuropathology

Identifiers

PMID25079797
PMCPMC5777140
OpenAlexW2164563480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.