ArticlePLoS pathogens2014
Israeli acute paralysis virus: epidemiology, pathogenesis and implications for honey bee health.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed, 209 citations in OpenAlex.
- Virus specific impacts on honey bee flight performance are mediated by the octopamine pathway.bioRxiv : the preprint server for biology · 2026Article
- Experimental infection of acute bee paralysis virus induces differential responses of selected honey bee immune genes, independent of varroa resistance.Scientific reports · 2026Article
- Viral influence on chemical communication in eusocial insects: insights and emerging research priorities.Journal of insect science (Online) · 2026Review
- Patterns of viral prevalence and load show independent circulation of some honey bee viruses in wild bees.Scientific reports · 2026Article
- Metagenomic and gene expression patterns in declining commercial honey bee colonies.Scientific reports · 2026Article
- Comprehensive virome analysis ofFrontiers in insect science · 2026Article
- Inapparent virus infections differentially affect honey bee flight.Science advances · 2025Article
- Mechanical transfer of honey bee (Hymenoptera: Apidae) virus sequences to wax by worker traffic and aerosolization.Journal of insect science (Online) · 2025Article
- Host Specificity ofInsects · 2025Article
- Gut-binding peptides as potential tools to reduce virus binding to honey bee gut surface proteins.Applied and environmental microbiology · 2025Article
- The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host.BMC genomics · 2025Article
- Characterisation of the virome ofThe Journal of general virology · 2025Article
- Article
- Regional patterns and climatic predictors of viruses in honey bee (Apis mellifera) colonies over time.Scientific reports · 2025Article
- Israeli Acute Paralysis Virus Is an Emerging Pathogen Contributing to Brood Disease ofViruses · 2024Article
- Mechanisms of Pathogen and Pesticide Resistance in Honey Bees.Physiology (Bethesda, Md.) · 2024Review
- First detection and prevalence of Apis mellifera filamentous virus in Apis mellifera and Varroa destructor in the Republic of Korea.Scientific reports · 2024Article
- Treatment of waxborne honey bee (Hymenoptera: Apidae) viruses using time, temperature, and electron-beam irradiation.Journal of economic entomology · 2024Article
- Seasonal trends of the ABPV, KBV, and IAPV complex in Italian managed honey bee (Apis mellifera L.) colonies.Archives of virology · 2024Article
- The effect of Israeli acute paralysis virus infection on honey bee brood care behavior.Scientific reports · 2024Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 20 institutions in 4 countries.
Funding
Abstract
Israeli acute paralysis virus (IAPV) is a widespread RNA virus of honey bees that has been linked with colony losses. Here we describe the transmission, prevalence, and genetic traits of this virus, along with host transcriptional responses to infections. Further, we present RNAi-based strategies for limiting an important mechanism used by IAPV to subvert host defenses. Our study shows that IAPV is established as a persistent infection in honey bee populations, likely enabled by both horizontal and vertical transmission pathways. The phenotypic differences in pathology among different strains of IAPV found globally may be due to high levels of standing genetic variation. Microarray profiles of host responses to IAPV infection revealed that mitochondrial function is the most significantly affected biological process, suggesting that viral infection causes significant disturbance in energy-related host processes. The expression of genes involved in immune pathways in adult bees indicates that IAPV infection triggers active immune responses. The evidence that silencing an IAPV-encoded putative suppressor of RNAi reduces IAPV replication suggests a functional assignment for a particular genomic region of IAPV and closely related viruses from the Family Dicistroviridae, and indicates a novel therapeutic strategy for limiting multiple honey bee viruses simultaneously and reducing colony losses due to viral diseases. We believe that the knowledge and insights gained from this study will provide a new platform for continuing studies of the IAPV-host interactions and have positive implications for disease management that will lead to mitigation of escalating honey bee colony losses worldwide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.