Observational studyInternational forum of allergy & rhinology2014
Sleep and quality of life improvements after endoscopic sinus surgery in patients with chronic rhinosinusitis.
Observational study in International forum of allergy & rhinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- The Impact of Rhinosinusitis and Its Treatment on Sleep-Disordered Breathing: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Sleep quality assessment in chronic rhinosinusitis patients submitted to endoscopic sinus surgery: a meta-analysis.Brazilian journal of otorhinolaryngologyPooled it
- Defining the minimal clinically important difference for olfactory outcomes in the surgical treatment of chronic rhinosinusitis.International forum of allergy & rhinology · 2017Trial
- Sensitivity analysis and diagnostic accuracy of the Brief Smell Identification Test in patients with chronic rhinosinusitis.International forum of allergy & rhinology · 2016Trial
- Health utility outcomes in patients undergoing medical management for chronic rhinosinusitis: a prospective multiinstitutional study.International forum of allergy & rhinology · 2015Trial
- Cognitive Dysfunction in Chronic Rhinosinusitis: A Scoping Review.International forum of allergy & rhinology · 2026Review
- Article
- Concordance Between an Adaptive Sino-Nasal Outcome Test and Imaging Results in Chronic Rhinosinusitis.JAMA otolaryngology-- head & neck surgery · 2026Article
- Sleep in disease: inflammation and chronic rhinosinusitis.Neurobiology of sleep and circadian rhythms · 2025Article
- Depression in patients with chronic otolaryngology symptoms - A vicious cycle.Head & face medicine · 2024Article
- Observational
- Prevalence and influencing factors of sleep disorders in patients with CRS: a protocol for systematic review and meta-analysis.BMJ open · 2023Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Understanding the CRSwNP Patient as Whole.American journal of rhinology & allergy · 2023Review
- What is the optimal outcome after endoscopic sinus surgery in the treatment of chronic rhinosinusitis? A consultation of Canadian experts.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2021Article
- Patient-reported sleep outcomes lack association with mucosal eosinophilia or neutrophilia in patients with chronic rhinosinusitis undergoing functional endoscopic sinus surgery.International forum of allergy & rhinology · 2021Article
- Long-term outcomes of endoscopic sinus surgery in the management of adult chronic rhinosinusitis.International forum of allergy & rhinology · 2019Observational
- Incident Chronic Rhinosinusitis Is Associated With Impaired Sleep Quality: Results of the RHINE Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Is greater antibiotic therapy prior to ESS associated with differences in surgical outcomes in CRS?The Laryngoscope · 2019Observational
- Does Delaying Endoscopic Sinus Surgery Adversely Impact Quality-of-Life Outcomes?The Laryngoscope · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRecent investigation has demonstrated that approximately 75% of patients with medically refractory chronic rhinosinusitis (CRS) report abnormal sleep quality, with strong correlation between worse sleep quality and more severe CRS disease severity. It remains unknown whether the treatment effect of endoscopic sinus surgery (ESS) for CRS results in appreciable sleep quality improvements.
methodsAdult patients (aged ≥18 years) with a current diagnosis of recalcitrant chronic rhinosinusitis (CRS), who voluntarily elected ESS as the next treatment modality (n = 301), were prospectively evaluated within 4 academic, tertiary care centers using treatment outcome instruments: the Rhinosinusitis Disability Index, the 22-item Sinonasal Outcome Test, the 2-item Patient Health Questionnaire, and the Pittsburgh Sleep Quality Index (PSQI) both before and after ESS.
resultsSeventy-two percent (72%) of patients with CRS were found to have poor sleep (PSQI > 5) at baseline with a mean (standard deviation) global PSQI score of 9.4 (4.6). Surgery improved overall mean global PSQI scores (by 2.2 points), and all 7 subdomain scores of the PSQI. Similarly, the odds of good sleep quality (PSQI ≤ 5) in patients treated with sinus surgery increased significantly (odds ratio [OR] 5.94; 95% confidence interval [CI], 3.06 to 11.53; p < 0.001). Stepwise multivariate linear regression found that acetylsalicylic acid (ASA) intolerance (β [standard error], -1.94 [0.93]; 95% CI, -3.77 to -0.11; p = 0.038), history of prior sinus surgery (β [standard error], 1.10 (0.54); 95% CI, 0.03 to 2.16; p = 0.044), and frontal sinusotomy (β [standard error], -1.03 [0.62]; 95% CI, -2.26 to 0.20; p = 0.099) were found to significantly associate with improvement in PSQI sleep scores.
conclusionAmong patients with CRS, reduced sleep quality, poor disease-specific quality of life, and greater disease severity were improved following ESS.
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Registered trials
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