ArticleBMC bioinformatics2014
Functional and genetic analysis of the colon cancer network.
Article in BMC bioinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- A Multi-Omics Overview of Colorectal Cancer to Address Mechanisms of Disease, Metastasis, Patient Disparities and Outcomes.Cancers · 2023Review
- mBAT-combo: A more powerful test to detect gene-trait associations from GWAS data.American journal of human genetics · 2023Article
- Severe testing with high-dimensional omics data for enhancing biomedical scientific discovery.NPJ systems biology and applications · 2022Article
- Analysis of Tumor-Infiltrating T-Cell Transcriptomes Reveal a Unique Genetic Signature across Different Types of Cancer.International journal of molecular sciences · 2022Article
- Comprehensive analyses of correlation and survival reveal informative lncRNA prognostic signatures in colon cancer.World journal of surgical oncology · 2021Article
- Identifying the hub gene and immune infiltration of osteoarthritis by bioinformatical methods.Clinical rheumatology · 2021Article
- Data-Driven Computational Social Network Science: Predictive and Inferential Models for Web-Enabled Scientific Discoveries.Frontiers in big data · 2021Article
- Network inference in systems biology: recent developments, challenges, and applications.Current opinion in biotechnology · 2020Review
- Prostate Cancer Gene Regulatory Network Inferred from RNA-Seq Data.Current genomics · 2019Article
- MicroRNA-4458 suppresses migration and epithelial-mesenchymal transition via targeting HMGA1 in non-small-cell lung cancer cells.Cancer management and research · 2019Article
- Ten hub genes associated with progression and prognosis of pancreatic carcinoma identified by co-expression analysis.International journal of biological sciences · 2018Article
- Epistasis analysis of microRNAs on pathological stages in colon cancer based on an Empirical Bayesian Elastic Net method.BMC genomics · 2017Article
- Biomarker correlation network in colorectal carcinoma by tumor anatomic location.BMC bioinformatics · 2017Article
- Mucin expression patterns in histological grades of colonic cancers in Ghanaian population.The Pan African medical journal · 2017Article
- Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data.BMC systems biology · 2015Article
- Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways.Frontiers in genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is a complex disease that has proven to be difficult to understand on the single-gene level. For this reason a functional elucidation needs to take interactions among genes on a systems-level into account. In this study, we infer a colon cancer network from a large-scale gene expression data set by using the method BC3Net. We provide a structural and a functional analysis of this network and also connect its molecular interaction structure with the chromosomal locations of the genes enabling the definition of cis- and trans-interactions. Furthermore, we investigate the interaction of genes that can be found in close neighborhoods on the chromosomes to gain insight into regulatory mechanisms. To our knowledge this is the first study analyzing the genome-scale colon cancer network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.