ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Shared genetic factors influence amygdala volumes and risk for alcoholism.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.Addiction biology · 2024Pooled it
- Alcohol-seeking associations with resting state functional connectivity of the amygdala.Drug and alcohol dependence · 2026Article
- Shared genetic effects among schizophrenia, substance use disorder, and hippocampal volume in a multiplex extended pedigree sample.Schizophrenia research · 2026Article
- Assessment of Brain Morphological Abnormalities and Neurodevelopmental Risk Copy Number Variants in Individuals from the UK Biobank.International journal of molecular sciences · 2025Article
- Molecular and biochemical pathologies in human alcohol-related cerebellar white matter degeneration.Advances in drug and alcohol research · 2025Article
- Neural responses to reward, threat, and emotion regulation and transition to hazardous alcohol use.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Phenome-wide association studies betweenFrontiers in psychiatry · 2024Article
- Ethanol-Induced Suppression of G Protein-Gated Inwardly Rectifying KBiological psychiatry · 2023Article
- Alcohol use and grey matter structure: Disentangling predispositional and causal contributions in human studies.Addiction biology · 2023Review
- Brain volumes in alcohol use disorder: Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis.Human brain mapping · 2023Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure.Communications biology · 2022Article
- Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study.JAMA psychiatry · 2022Article
- Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder.Molecular psychiatry · 2021Article
- Accelerated Aging of the Amygdala in Alcohol Use Disorders: Relevance to the Dark Side of Addiction.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Pre-training naltrexone increases conditioned fear learning independent of adolescent alcohol consumption history.Physiology & behavior · 2021Article
- Convergent Evidence for Predispositional Effects of Brain Gray Matter Volume on Alcohol Consumption.Biological psychiatry · 2020Article
- Alcohol Induced Brain and Liver Damage: Advantages of a Porcine Alcohol Use Disorder Model.Frontiers in physiology · 2020Review
- Morphometric Biomarkers of Adolescents With Familial Risk for Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2019Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Alcohol abuse and dependence (alcohol use disorders, AUDs) are associated with brain shrinkage. Subcortical structures including the amygdala, hippocampus, ventral striatum, dorsal striatum, and thalamus subserve reward functioning and may be particularly vulnerable to alcohol-related damage. These structures may also show pre-existing deficits impacting the development and maintenance of AUD. It remains unclear whether there are common genetic features underlying both subcortical volumes and AUD. In this study, structural brain images were acquired from 872 Mexican-American individuals from extended pedigrees. Subcortical volumes were obtained using FreeSurfer, and quantitative genetic analyses were performed in SOLAR. We hypothesized the following: (1) reduced subcortical volumes in individuals with lifetime AUD relative to unrelated controls; (2) reduced subcortical volumes in individuals with current relative to past AUD; (3) in non-AUD individuals, reduced subcortical volumes in those with a family history of AUD compared to those without; and (4) evidence for common genetic underpinnings (pleiotropy) between AUD risk and subcortical volumes. Results showed that individuals with lifetime AUD showed larger ventricular and smaller amygdala volumes compared to non-AUD individuals. For the amygdala, there were no differences in volume between current vs past AUD, and non-AUD individuals with a family history of AUD demonstrated reductions compared to those with no such family history. Finally, amygdala volume was genetically correlated with the risk for AUD. Together, these results suggest that reduced amygdala volume reflects a pre-existing difference rather than alcohol-induced neurotoxic damage. Our genetic correlation analysis provides evidence for a common genetic factor underlying both reduced amygdala volumes and AUD risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.