SynthesisAnnals of the American Thoracic Society2014
Malignant mesothelioma and central nervous system metastases. Report of two cases, pooled analysis, and systematic review.
Synthesis in Annals of the American Thoracic Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Genetic and Immunohistochemical Profiling of Malignant Mesothelioma With Brain Metastasis: A Report of Two Cases.Cancer reports (Hoboken, N.J.) · 2026Article
- Brain Metastases in Diffuse Pleural Mesothelioma: Clinical, Histologic, and Molecular Correlates.JTO clinical and research reports · 2026Article
- Incidence and Outcomes of Brain Metastasis in Pleural Mesothelioma in the Era of Immunotherapy.JTO clinical and research reports · 2025Article
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- Article
- Rare thoracic cancers: a comprehensive overview of diagnosis and management of small cell lung cancer, malignant pleural mesothelioma and thymic epithelial tumours.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Donut sign: a unique radiological sign of cerebral metastasis in malignant mesothelioma.BMJ case reports · 2022Article
- Article
- Cerebral metastases of malignant mesothelioma.Journal of surgical case reports · 2022Article
- A case of brain metastasis with pathological transformation of long-surviving malignant pleural mesothelioma: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Successful treatment of a patient with oligometastatic mesothelioma to the brain.JTCVS techniques · 2020Article
- Commentary: When cancer is oligometastatic, even mesothelioma is curable.JTCVS techniques · 2020Article
- Mesothelium and Malignant Mesothelioma.Journal of developmental biology · 2019Review
- Metastatic biphasic pleural mesothelioma presenting with cauda equina syndrome.Radiology case reports · 2018Article
- Proton beam therapy for malignant pleural mesothelioma.Translational lung cancer research · 2018Review
- Brain metastases in malignant pleural mesothelioma.Clinical & experimental metastasis · 2016Article
- Biphasic Malignant Pleural Mesothelioma Masquerading as a Primary Skeletal Tumor.Case reports in pulmonology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleThe incidence and patterns of metastatic disease to the central nervous system (CNS) from malignant mesothelioma are not well characterized.
objectivesWe describe the treatment of two cases of pleural mesothelioma with CNS metastases. We also report the results of a systematic review with pooled data analysis of CNS metastases from malignant mesothelioma.
methodsPubMed, Scopus, EMBASE, and Web of Science were searched to identify relevant published studies. Inclusion criteria for the pooled analysis were any clinical or autopsy study in which patients had a confirmed histological diagnosis of malignant mesothelioma and CNS metastasis was identified by autopsy, clinical pathological specimen, or compelling radiographic imaging. Case reports were excluded from the pooled analysis but were incorporated into the discussion. One hundred forty-one potentially relevant references were identified. Seven studies including 655 patients were included in the pooled analysis. Ninety-seven additional cases were identified and incorporated into the discussion. A systematic review of the literature is provided with pooled data analysis. MEASUREMENTS AND MAIN
resultsCNS involvement of malignant mesothelioma may occur by hematogenous spread or by local extension. Some cases may represent tumor dedifferentiation to a more aggressive histologic subtype. Surgery or stereotactic therapies may play a role for select patients; however, rapid recurrence has been reported.
conclusionsThe prognostic significance of CNS disease is not well characterized. Clinicians should consider and identify CNS involvement in patients with new or evolving neurologic symptoms because early identification may allow for palliative intervention.
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