Evidence map›Paper›PMID 25079073›Full record

ArticlePLoS genetics2014

The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.

Michael L Salmans, Zhengquan Yu, Kazuhide Watanabe, Eric Cam, Peng Sun, Padhraic Smyth, Xing Dai, Bogi Andersen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Michael L SalmansDepartment of Biological Chemistry, University of California, Irvine, Irvine, California, United States of America; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, California, United States of America.
Zhengquan YuState Key Laboratories for AgroBiotechnology, College of Biological Sciences, China Agricultural University, Beijing, PR China.
Kazuhide WatanabeDepartment of Biological Chemistry, University of California, Irvine, Irvine, California, United States of America.
Eric CamDepartment of Biological Chemistry, University of California, Irvine, Irvine, California, United States of America.
Peng SunDepartment of Biological Chemistry, University of California, Irvine, Irvine, California, United States of America.
Padhraic SmythInstitute for Genomics and Bioinformatics, University of California, Irvine, Irvine, California, United States of America; Department of Computer Science, University of California, Irvine, Irvine, California, United States of America.
Xing DaiDepartment of Biological Chemistry, University of California, Irvine, Irvine, California, United States of America.
Bogi AndersenDepartment of Biological Chemistry, University of California, Irvine, Irvine, California, United States of America; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, California, United States of America; Department of Medicine, University of California, Irvine, Irvine, California, United States of America.
University of California, Irvine · USChina Agricultural University · CN

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Transcriptional Co-Regulators in EpidermisR01AR044882 · NIAMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI Bogi Andersen · 1998 to 2026
$9.0M
NCI NIH HHS P30 CA062203NIAMS NIH HHS AR44882NIAMS NIH HHS R01 AR044882NLM NIH HHS T15LM0744
6 · The paper itself

Abstract

Mammary gland branching morphogenesis and ductal homeostasis relies on mammary stem cell function for the maintenance of basal and luminal cell compartments. The mechanisms of transcriptional regulation of the basal cell compartment are currently unknown. We explored these mechanisms in the basal cell compartment and identified the Co-factor of LIM domains (CLIM/LDB/NLI) as a transcriptional regulator that maintains these cells. Clims act within the basal cell compartment to promote branching morphogenesis by maintaining the number and proliferative potential of basal mammary epithelial stem cells. Clim2, in a complex with LMO4, supports mammary stem cells by directly targeting the Fgfr2 promoter in basal cells to increase its expression. Strikingly, Clims also coordinate basal-specific transcriptional programs to preserve luminal cell identity. These basal-derived cues inhibit epidermis-like differentiation of the luminal cell compartment and enhance the expression of luminal cell-specific oncogenes ErbB2 and ErbB3. Consistently, basal-expressed Clims promote the initiation and progression of breast cancer in the MMTV-PyMT tumor model, and the Clim-regulated branching morphogenesis gene network is a prognostic indicator of poor breast cancer outcome in humans.

Indexed as

Adaptor Proteins, Signal TransducingBreast NeoplasmsCarcinogenesisCell DifferentiationDNA-Binding ProteinsEpithelial CellsErb-b2 Receptor Tyrosine KinasesFemaleGene Expression Regulation, NeoplasticHumansLIM Domain ProteinsMammary Glands, HumanNeoplasms, Basal CellPromoter Regions, GeneticProtein Structure, TertiaryReceptor, Fibroblast Growth Factor, Type 2Adaptor Proteins, Signal TransducingDNA-Binding ProteinsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesFGFR2 protein, humanLDB1 protein, humanLIM Domain ProteinsLMO4 protein, humanReceptor, Fibroblast Growth Factor, Type 2Transcription Factors

Identifiers

PMID25079073
PMCPMC4117441
OpenAlexW1980420918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.