ArticleJournal of perinatology : official journal of the California Perinatal Association2015
Increased expression of prostasin contributes to early-onset severe preeclampsia through inhibiting trophoblast invasion.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Comparative and diagnostic evaluation of maternal serum prostasin in early-onset preeclampsia.Medicine · 2026Article
- Article
- Article
- Implications for preeclampsia: hypoxia-induced Notch promotes trophoblast migration.Reproduction (Cambridge, England) · 2021Article
- Retinol-binding protein 4 regulates the biological functions and molecular mechanisms of JEG-3 cells.International journal of clinical and experimental pathology · 2018Article
- ANGPTL4 mediates the protective role of PPARγ activators in the pathogenesis of preeclampsia.Cell death & disease · 2017Article
- Notch2 and Notch3 suppress the proliferation and mediate invasion of trophoblast cell lines.Biology open · 2017Article
- Transthyretin regulates the migration and invasion of JEG-3 cells.Oncology letters · 2017Article
- Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase.BMC cancer · 2015Article
- Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the potential role of prostasin, as an invasion suppressor, in the process of trophoblast invasion in preeclampsia. STUDY
designThis case-control study included 19 early-onset severe preeclampsia (⩽ 34 weeks), 20 late-onset severe preeclampsia (>34 weeks) and 20 normal term pregnant women. Immunohistochemistry was conducted to identify the cellular localization of prostasin, as well as the matrix metalloproteinase 2 (MMP2) and MMP9 in the placenta tissues. Enzyme-linked immunosorbent assay was performed to analyze the expression of these three proteins in placental homogenates. The effect of prostasin on the invasive and migratory ability of trophoblast cells was detected by transwell assays. We also examined the regulation of the prostasin antibody in the MMP2 and MMP9 secretion by HTR-8/SVneo cells via blocking the prostasin activity.
resultThis study demonstrated that the prostasin, MMP2 and MMP9 were all expressed in the placental syncytiotrophoblasts. Increased expression of prostasin was detected in cases with early-onset severe preeclampsia compared with the late-onset and control groups (P < 0.05), whereas the expression patterns of MMP2 and MMP9 in placental homogenates were opposite to that of prostasin (P < 0.05). Recombinant prostasin inhibited the invasion and migration of trophoblast cells, whereas prostasin antibody enhanced the MMP2 and MMP9 secretion in a dose- and time-dependent manner.
conclusionThese findings suggest that prostasin may suppress the invasion process in preeclampsia by attenuating MMP2 and MMP9 secretion.
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