ArticleJournal of perinatology : official journal of the California Perinatal Association2014
Can a national dataset generate a nomogram for necrotizing enterocolitis onset?
Article in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bifidobacterium and Lactobacillus for preventing necrotizing enterocolitis in very-low-birth-weight preterm infants: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2020Pooled it
- Are Immune Modulating Single Nucleotide Polymorphisms Associated with Necrotizing Enterocolitis?Scientific reports · 2015Trial
- When It Is Not NEC: Recognizing Mimics of Necrotizing Enterocolitis in Preterm Infants.Children (Basel, Switzerland) · 2026Review
- Probiotics and necrotizing enterocolitis in preterm infants after the food and drug administration warning actions.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Is necrotizing enterocolitis associated with the 896A/G polymorphism in the toll-like receptor 4 (TLR4) gene?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026Article
- Necrotizing enterocolitis following spontaneous intestinal perforation in very low birth weight neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Risk factor analysis and nomogram prediction model construction for NEC complicated by intestinal perforation.BMC pediatrics · 2024Article
- Factors associated with the increased incidence of necrotising enterocolitis in extremely preterm infants in Sweden between two population-based national cohorts (2004-2007 vs 2014-2016).Archives of disease in childhood. Fetal and neonatal edition · 2023Article
- Spontaneous intestinal perforation (SIP) will soon become the most common form of surgical bowel disease in the extremely low birth weight (ELBW) infant.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Time of Onset of Necrotizing Enterocolitis and Focal Perforation in Preterm Infants: Impact on Clinical, Surgical, and Histological Features.Frontiers in pediatrics · 2021Article
- Probiotic Use and Safety in the Neonatal Intensive Care Unit: A Matched Cohort Study.The Journal of pediatrics · 2020Article
- Neonatal necrotizing enterocolitis: a case series examining clinical diagnosis with discrepant versus concordant autopsy results.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Preterm neonatal immunology at the intestinal interface.Cellular and molecular life sciences : CMLS · 2020Review
- Association of Adverse Hearing, Growth, and Discharge Age Outcomes With Postnatal Cytomegalovirus Infection in Infants With Very Low Birth Weight.JAMA pediatrics · 2020Article
- Prediction of intestinal failure from necrotizing enterocolitis following surgery: A multicenter retrospective review.Medicine · 2019Article
- Racial/ethnic differences in necrotizing enterocolitis incidence and outcomes in premature very low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- IL-17 in neonatal health and disease.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Review
- Postoperative characteristics of infants who developed necrotizing enterocolitis with different postnatal ages.Medicine · 2017Observational
- Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- The complete blood cell count in a refined cohort of preterm NEC: the importance of gestational age and day of diagnosis when using the CBC to estimate mortality.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMother's own milk and donor human milk use is increasing as a means of necrotizing enterocolitis (NEC) prevention. Early onset of enteral feeding has been associated with improvement of many outcomes but has not been shown to reduce the incidence of NEC. Better definition of the window of risk for NEC by gestational strata should improve resource management with respect to donor human milk and enhance our understanding of NEC timing and pathogenesis. Our objective was to establish a NEC dataset of sufficient size and quality, then build a generalizable model of NEC onset from the dataset across gestational strata. STUDY
designWe used de-identified data from the Pediatrix national dataset and filtered out all diagnostic confounders that could be identified by either specific diagnoses or logical exclusions (example dual diagnoses), with a specific focus on NEC and spontaneous intestinal perforation (SIP) as the outcomes of interest. The median day of onset was plotted against the gestational age for each of these diagnoses and analyzed for similarities and differences in the day of diagnosis.
resultOnset time of medical NEC was inversely proportional to gestation in a linear relationship across all gestational ages. We found the medical NEC dataset displayed characteristics most consistent with a homogeneous disease entity, whereas there was a skew towards early presentation in the youngest gestation groups of surgical NEC (suggesting probable SIP contamination).
conclusionOur national dataset demonstrates that NEC onset occurs in an inverse stereotypic, linear relationship with gestational age at birth. Medical NEC is the most reliable sub-cohort for the purpose of determining the temporal window of NEC risk.
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