ArticleNature communications2014
Enhancing the fidelity of neurotransmission by activity-dependent facilitation of presynaptic potassium currents.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms.Journal of cell communication and signaling · 2026Review
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- Intersectin-1 enhances calcium-dependent replenishment of the readily releasable pool of synaptic vesicles during development.The Journal of physiology · 2025Article
- CMOS-integrated organic neuromorphic imagers for high-resolution dual-modal imaging.Nature communications · 2025Article
- Biomimetic Neuromorphic Sensory System via Electrolyte Gated Transistors.Sensors (Basel, Switzerland) · 2024Review
- What calcium channels remember.eLife · 2023Article
- Article
- Article
- Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury.Acta neuropathologica communications · 2022Article
- KCNQ Channels Enable Reliable Presynaptic Spiking and Synaptic Transmission at High Frequency.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Advances in the study of axon-associated vesicles.Frontiers in molecular neuroscience · 2022Review
- Using ephaptic coupling to estimate the synaptic cleft resistivity of the calyx of Held synapse.PLoS computational biology · 2021Article
- Large, Stable Spikes Exhibit Differential Broadening in Excitatory and Inhibitory Neocortical Boutons.Cell reports · 2021Article
- Nitric Oxide Signaling in the Auditory Pathway.Frontiers in neural circuits · 2021Review
- The potassium channel subunit KProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain.Molecular psychiatry · 2020Article
- Timing constraints of action potential evoked CaScientific reports · 2019Article
- Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules.Nature communications · 2019Article
- The subthreshold-active KCommunications biology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Neurons convey information in bursts of spikes across chemical synapses where the fidelity of information transfer critically depends on synaptic input-output relationship. With a limited number of synaptic vesicles (SVs) in the readily releasable pool (RRP), how nerve terminals sustain transmitter release during intense activity remains poorly understood. Here we report that presynaptic K(+) currents evoked by spikes facilitate in a Ca(2+)-independent but frequency- and voltage-dependent manner. Experimental evidence and computer simulations demonstrate that this facilitation originates from dynamic transition of intermediate gating states of voltage-gated K(+) channels (Kvs), and specifically attenuates spike amplitude and inter-spike potential during high-frequency firing. Single or paired recordings from a mammalian central synapse further reveal that facilitation of Kvs constrains presynaptic Ca(2+) influx, thereby efficiently allocating SVs in the RRP to drive postsynaptic spiking at high rates. We conclude that presynaptic Kv facilitation imparts neurons with a powerful control of transmitter release to dynamically support high-fidelity neurotransmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.