ArticleArthritis research & therapy2014
Psoriatic arthritis and sacroiliitis are associated with increased vascular inflammation by 18-fluorodeoxyglucose positron emission tomography computed tomography: baseline report from the Psoriasis Atherosclerosis and Cardiometabolic Disease Initiative.
Article in Arthritis research & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Cholesterol efflux capacity in humans with psoriasis is inversely related to non-calcified burden of coronary atherosclerosis.European heart journal · 2015Trial
- Molecular imaging of psoriatic arthritis.Current opinion in rheumatology · 2025Review
- Cardiovascular Disease and Cardiac Imaging in Inflammatory Arthritis.Life (Basel, Switzerland) · 2023Review
- Positron emission tomographic studies of the association between atherogenesis and aortitis among psoriatic patients.Archives of medical science : AMS · 2023Article
- PET/CT-Based Characterization of 18F-FDG Uptake in Various Tissues Reveals Novel Potential Contributions to Coronary Artery Disease in Psoriatic Arthritis.Frontiers in immunology · 2022Article
- Article
- The application of molecular imaging to advance translational research in chronic inflammation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Review
- [Obesity - A Risk Factor for Psoriasis and COVID-19].Actas dermo-sifiliograficas · 2021Review
- Applying precision medicine to unmet clinical needs in psoriatic disease.Nature reviews. Rheumatology · 2020Review
- The History of Psoriatic Arthritis (PsA): From Moll and Wright to Pathway-Specific Therapy.Current rheumatology reports · 2018Review
- Editorial: Tumor Necrosis Factor Antagonists: Killing Two Birds With One Biologic Stone.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- Potential Immunological Links Between Psoriasis and Cardiovascular Disease.Frontiers in immunology · 2018Review
- Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis.International journal of molecular sciences · 2017Review
- Cardiometabolic Disorders in Psoriatic Disease.Current rheumatology reports · 2017Review
- Updates on cardiovascular comorbidities associated with psoriatic diseases: epidemiology and mechanisms.Rheumatology international · 2017Review
- Feasibility of carotid artery PET/MRI in psoriasis patients.American journal of nuclear medicine and molecular imaging · 2016Article
- Improving cardiovascular health and metabolic comorbidities in patients with psoriatic arthritis.International journal of clinical rheumatology · 2015Article
- Atherosclerosis in psoriatic disease: latest evidence and clinical implications.Therapeutic advances in musculoskeletal disease · 2015Review
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Authors and funding
6 authors at 6 institutions in 1 country.
Funding
Abstract
introductionPsoriasis and psoriatic arthritis (PsA) increase cardiovascular disease (CVD) risk, but surrogate markers for CVD in these disorders are inadequate. Because the presence of sacroiliitis may portend more severe PsA, we hypothesized that sacroiliitis defined by computed tomography (CT) would be associated with increased vascular inflammation defined by 18-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT), which is an established measure of CVD.
methodsParticipants (n = 65) underwent whole-body FDG-PET/CT. Metabolic activity of the aorta was measured using the maximal standardized uptake value (SUVmax), a measure of atherosclerotic plaque activity. The primary outcome was aortic vascular inflammation. Linear regression (with β-coefficients (β) and P-values reported for PsA and sacroiliitis) was used to adjust for CVD risk factors to determine associations of PsA or sacroiliitis with vascular inflammation. Likelihood ratio testing was performed to evaluate the contribution of sacroiliitis to vascular disease estimation compared to the effects of PsA and traditional CVD risk factors.
resultsVascular inflammation (measured as SUVmax) was greater (P < 0.001) in patients with sacroiliitis (mean ± SD = 7.33 ± 2.09) defined by CT compared to those without sacroiliitis (6.39 ± 1.49, P = 0.038). There were associations between PsA and aortic inflammation (β = 0.124, P < 0.001) and between sacroiliitis and aortic inflammation (β = 0.270, P < 0.001) after adjusting for CVD risk factors. Sacroiliitis predicted vascular inflammation beyond PsA and CVD risk factors (χ2 = 124.6, P < 0.001).
conclusionsSacroiliitis is associated with increased vascular inflammation detected by FDG-PET/CT, suggesting that sacroiliac joint disease may identify patients at greater risk for CVD. Large, ongoing prospective studies are required to confirm these findings.
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