ArticleThe Journal of investigative dermatology2015
The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- mRNAome Analysis of Whole Blood of Patients with Psoriatic Arthritis, Ankylosing Spondylitis, and Rheumatoid Arthritis.Current rheumatology reviews · 2026Review
- Epidermal maintenance of Langerhans cells relies on autophagy-regulated lipid metabolism.The Journal of cell biology · 2025Article
- Immunological control of skin development: from homeostasis to developmental pathologies.Frontiers in immunology · 2025Review
- The Ragulator complex: delving its multifunctional impact on metabolism and beyond.Inflammation and regeneration · 2023Review
- Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling.Science advances · 2023Article
- The attenuation effect of potassium 2-(1-hydroxypentyl)-benzoate in a mouse model of diabetes-associated cognitive decline: The protein expression in the brain.CNS neuroscience & therapeutics · 2022Article
- LAMTOR/Ragulator regulates lipid metabolism in macrophages and foam cell differentiation.FEBS letters · 2020Article
- Metabolic Control of Dendritic Cell Functions: Digesting Information.Frontiers in immunology · 2019Review
- Langerhans Cells: Sensing the Environment in Health and Disease.Frontiers in immunology · 2018Review
- LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.The Journal of cell biology · 2017Article
- Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling.The Journal of experimental medicine · 2017Article
- Ontogeny and function of murine epidermal Langerhans cells.Nature immunology · 2017Review
- TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance.Allergy · 2016Review
- Article
- Langerhans cell origin and regulation.Current opinion in hematology · 2016Review
- The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Langerhans cells (LCs), a sub-population of dendritic cells (DCs) in the skin, participate in the regulation of immunity and peripheral tolerance. The adaptor molecule p14 is part of the late endosomal/lysosomal adaptor and mitogen-activated protein kinase and mammalian target of rapamycin (mTOR) activator/regulator (LAMTOR) complex, which mediates the activation of lysosome-associated extracellular signaling-regulated kinase (ERK) and the mTOR cascade. In previous work, we demonstrated that CD11c-specific deficiency of p14 disrupts LC homeostasis by affecting the LAMTOR-mediated ERK and mTOR signaling. In this study, we extended our analysis on p14 deficiency specifically in LCs. Langerin-specific ablation of p14 caused a complete loss of LCs, accompanied by an increased maturational phenotype of LCs. The absence of LCs in p14-deficient mice reduced contact hypersensitivity (CHS) responses to the contact sensitizer trinitrochlorobenzene. Analysis using bone marrow-derived DCs (BMDCs) revealed that p14 deficiency in DCs/LCs interfered with the LC-relevant transforming growth factor β1 (TGFβ1) pathway, by lowering TGFβ receptor II expression on BMDCs and LCs, as well as surface binding of TGFβ1 on BMDCs. We conclude that p14 deficiency affects TGFβ1 sensitivity of LCs, which is mandatory for their homeostasis and subsequently for their immunological function during CHS.
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