ArticleDevelopment (Cambridge, England)2014
FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 89 citations in OpenAlex.
- Establishing a long-term versatile culture system for functional mouse mammary organoids from single cells.Nature protocols · 2026Review
- Enforced ZFP281 expression delays breast cancer initiation and can provide lifelong protection against breast cancer metastasis.bioRxiv : the preprint server for biology · 2026Article
- Contractile fibroblasts form a transient niche for the branching mammary epithelium.Nature communications · 2025Article
- Morphogenic, molecular and cellular adaptations for unidirectional airflow in the chicken lung.Development (Cambridge, England) · 2025Article
- The dynamics of tubulogenesis in development and disease.Development (Cambridge, England) · 2025Review
- Embryonic Mammary Gland Morphogenesis.Advances in experimental medicine and biology · 2025Review
- Implications of obesity and insulin resistance for the treatment of oestrogen receptor-positive breast cancer.British journal of cancer · 2024Review
- Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Sprouty genes regulate activated fibroblasts in mammary epithelial development and breast cancer.Cell death & disease · 2024Article
- Expanding the evo-devo toolkit: generation of 3D mammary tissue from diverse mammals.Development (Cambridge, England) · 2024Article
- A xenotransplantation mouse model to study physiology of the mammary gland from large mammals.PloS one · 2024Article
- A Decision Tree to Guide Human and Mouse Mammary Organoid Model Selection.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Reconstruction of dynamic mammary mini gland in vitro for normal physiology and oncogenesis.Nature methods · 2023Article
- Modeling the complexity of mammary gland in vitro.Nature methods · 2023Article
- FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation.Nature communications · 2023Article
- Unlocking Translational Potential: Conditionally Reprogrammed Cells in Advancing Breast Cancer Research.Cells · 2023Review
- miR-203 drives breast cancer cell differentiation.Breast cancer research : BCR · 2023Article
- FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation.Journal of mammary gland biology and neoplasia · 2023Article
- Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 axis.NPJ Regenerative medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
FGF signaling is essential for mammary gland development, yet the mechanisms by which different members of the FGF family control stem cell function and epithelial morphogenesis in this tissue are not well understood. Here, we have examined the requirement of Fgfr2 in mouse mammary gland morphogenesis using a postnatal organ regeneration model. We found that tissue regeneration from basal stem cells is a multistep event, including luminal differentiation and subsequent epithelial branching morphogenesis. Basal cells lacking Fgfr2 did not generate an epithelial network owing to a failure in luminal differentiation. Moreover, Fgfr2 null epithelium was unable to undergo ductal branch initiation and elongation due to a deficiency in directional migration. We identified FGF10 and FGF2 as stromal ligands that control distinct aspects of mammary ductal branching. FGF10 regulates branch initiation, which depends on directional epithelial migration. By contrast, FGF2 controls ductal elongation, requiring cell proliferation and epithelial expansion. Together, our data highlight a pleiotropic role of Fgfr2 in stem cell differentiation and branch initiation, and reveal that different FGF ligands regulate distinct aspects of epithelial behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.