ReviewCurrent opinion in immunology2014
Genetics of gene expression in immunity to infection.
Review in Current opinion in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 123 citations in OpenAlex.
- p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus.The Journal of clinical investigation · 2019Trial
- Integrated Molecular and Hematobiochemical Biomarkers for the Detection of Bovine Babesiosis in Holstein Calves.Veterinary sciences · 2026Article
- Multi-omics Data Integration.Advances in experimental medicine and biology · 2026Review
- History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.PLoS genetics · 2024Article
- Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity.Nature communications · 2023Article
- Individual Genomic Loci and mRNA Levels of Immune Biomarkers Associated with Pneumonia Susceptibility in Baladi Goats.Veterinary sciences · 2023Article
- New Insights on Nucleotide Sequence Variants and mRNA Levels of Candidate Genes Assessing Resistance/Susceptibility to Mastitis in Holstein and Montbéliarde Dairy Cows.Veterinary sciences · 2023Article
- Article
- Human genetic diversity regulating theHGG advances · 2022Article
- Article
- Identification of loci associated with susceptibility to bovine paratuberculosis and with the dysregulation of the MECOM, eEF1A2, and U1 spliceosomal RNA expression.Scientific reports · 2021Article
- Single cell profiling of capillary blood enables out of clinic human immunity studies.Scientific reports · 2020Article
- Article
- Interferon-α enhances the IL-12-induced STAT4 activation selectively in carriers of theAnnals of the rheumatic diseases · 2019Article
- Identification and characterization of GLDC as host susceptibility gene to severe influenza.EMBO molecular medicine · 2019Article
- Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation ofGenome research · 2018Article
- Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes.Genes · 2018Review
- Changes in macrophage transcriptome associate with systemic sclerosis and mediateAnnals of the rheumatic diseases · 2018Article
- Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease.Nature genetics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mapping gene expression as a quantitative trait (eQTL mapping) can reveal local and distant associations with functionally important genetic variation informative for disease. Recent studies are reviewed which have demonstrated that this approach is particularly informative when applied to diverse immune cell populations and situations relevant to infection and immunity. Context-specific eQTL have now been characterised following endotoxin activation, induction with interferons, mycobacteria, and influenza, together with genetic determinants of response to vaccination. The application of genetical genomic approaches offers new opportunities to advance our understanding of gene-environment interactions and fundamental processes in innate and adaptive immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.