SynthesisJournal of human hypertension2015
Effect of aldosterone antagonists on blood pressure in patients with resistant hypertension: a meta-analysis.
Synthesis in Journal of human hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- 7th Brazilian Guideline of Arterial Hypertension: Chapter 13 - Resistant Arterial HypertensionArquivos brasileiros de cardiologia · 2016Guideline
- Effect of Sequential Nephron Blockade versus Dual Renin-Angiotensin System Blockade Plus Bisoprolol in the Treatment of Resistant Hypertension, a Randomized Controlled Trial (Resistant Hypertension on Treatment - ResHypOT).Vascular health and risk management · 2022Trial
- Ambulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers plus hydrochlorothiazide in uncontrolled hypertensive patients.Drug design, development and therapy · 2017Trial
- Blood pressure control and its associated factors among patients with heart failure in Jordan.Journal of human hypertension · 2023Article
- Pharmacotherapy for Essential Hypertension: A Brief Review.Methodist DeBakey cardiovascular journal · 2022Review
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Resistant Hypertension in Chronic Kidney Disease (CKD): Prevalence, Treatment Particularities, and Research Agenda.Current hypertension reports · 2020Review
- The prevalence and predictors of resistant hypertension in high-risk overweight and obese patients: A cross-sectional study based on the 2017 ACC/AHA guidelines.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- KDOQI US Commentary on the 2017 ACC/AHA Hypertension Guideline.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Review
- Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysis.Journal of human hypertension · 2017Article
- A Network Meta-Analysis of Clinical Management Strategies for Treatment-Resistant Hypertension: Making Optimal Use of the Evidence.Journal of general internal medicine · 2017Review
- Managing resistant hypertension: focus on mineralocorticoid-receptor antagonists.Vascular health and risk management · 2017Review
- Multidisciplinary Approach in the Treatment of Resistant Hypertension.Current hypertension reports · 2017Review
- Three drugs and still hypertensive: what's left?Canadian family physician Medecin de famille canadien · 2016Review
- Emerging concepts for patients with treatment-resistant hypertension.Trends in cardiovascular medicine · 2016Review
- Resistant Hypertension and Chronic Kidney Disease: a Dangerous Liaison.Current hypertension reports · 2016Review
- Aldosterone and the Mineralocorticoid Receptor: Risk Factors for Cardiometabolic Disorders.Current hypertension reports · 2015Review
- Brazilian Position Statement on Resistant Hypertension - 2020.Arquivos brasileiros de cardiologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is currently limited data on which drug should be used to improve blood pressure (BP) control in patients with resistant hypertension (RH). We performed a systematic review and meta-analysis of published studies evaluating the anti-hypertensive benefit of aldosterone antagonists (AA) as an add-on therapy in patients with RH. A systematic literature search for eligible studies was conducted until June 2014, using literature databases and hand search. Studies were stratified according to controlled vs uncontrolled design and analyzed using random-effect models. We identified 13 eligible studies involving a total of 2640 patients, consisting of 3 randomized controlled trials, and 10 observational studies without a control group. In controlled studies, there was a reduction in mean systolic and diastolic BP of -16.5 (95% confidence interval (CI), -30.0 to -3.0) and -4.1 (95% CI, -7.8 to -0.32) mm Hg, respectively, compared with control. In uncontrolled studies, there was a reduction in mean systolic and diastolic BP of -19.7 (95% CI, -23.2 to -16.2) and -9.1 (95% CI, -10.3 to -7.8) mm Hg, respectively, compared with pre-AA therapy. Subgroup analysis showed that the systolic BP change was more pronounced in patients with baseline systolic BP >150 mm Hg (weighted mean difference (WMD), -23.1 mm Hg) than in patients with ⩽150 mm Hg (WMD, -15.4 mm Hg) (between groups P<0.001), suggesting that the baseline systolic BP was a predictor of the BP response to AA treatment. Furthermore, AA demonstrated a mild increase in serum potassium and creatinine (for both, P<0.001). The findings suggest that AA as an add-on therapy was effective for lowering systolic and diastolic BP in patients with RH.
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