Evidence map›Paper›PMID 25078446›Full record

ArticleOrganic & biomolecular chemistry2014

L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials.

Fan Zhao, Balthasar A Heesters, Isaac Chiu, Yuan Gao, Junfeng Shi, Ning Zhou, Michael C Carroll, Bing Xu

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Co-assembledInternational journal of pharmaceutics: X · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Fan ZhaoDepartment of Chemistry, Brandeis University, 415 South St. MS015, Waltham, Massachusetts 02454, USA. bxu@brandeis.edu.
Balthasar A Heesters
Isaac Chiu
Yuan Gao
Junfeng Shi
Ning Zhou
Michael C Carroll
Bing Xu
Brandeis University · USBoston Children's Hospital · USHarvard University · USUniversity Medical Center Utrecht · NL

Funding

Visualizing Effects of Costimulation on Antiviral ImmunityP01AI078897 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2008 to 2012
$12.1M
Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026
$6.4M
COMPLEMENT SYSTEM AND HUMORAL IMMUNITYR01AI039246 · NIAID · IMMUNE DISEASE INSTITUTE, INC. · PI CARROLL, MICHAEL CRAIG · 1996 to 2014
$6.1M
NCI NIH HHS CA142746NCI NIH HHS R01 CA142746NIAID NIH HHS AI039246NIAID NIH HHS AI078897NIAID NIH HHS P01 AI078897NIAID NIH HHS R01 AI039246
6 · The paper itself

Abstract

An l-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, in contrast to the properties of monomeric l-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the first example of the supramolecular assemblies of a saccharide to suppress immunity, this work illustrates a new approach of immunomodulation.

Indexed as

Adjuvants, ImmunologicAnimalsAntigen-Presenting CellsAntigensDNAEnzyme-Linked Immunosorbent AssayEpitopesFluorescent DyesGlycopeptidesHumansHydrogelsHydrogen-Ion ConcentrationImmune SystemImmunoglobulin GImmunoglobulin MImmunosuppressive AgentsAdjuvants, ImmunologicAntigensDNAEpitopesFluorescent DyesGlycopeptidesHydrogelsImmunoglobulin GImmunoglobulin MImmunosuppressive AgentsLiposomesMicellesPeptidesRhamnose

Identifiers

PMID25078446
PMCPMC4160809
OpenAlexW2073571484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.