ArticleJournal of molecular neuroscience : MN2015
Different microRNA profiles in chronic epilepsy versus acute seizure mouse models.
Article in Journal of molecular neuroscience : MN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The levels of miR-155 in epilepsy patients: a meta-analysis.Frontiers in neurology · 2025Pooled it
- Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy.Scientific reports · 2017Pooled it
- MiR-30a-5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β-catenin pathway.Epilepsia open · 2026Article
- The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis.Functional & integrative genomics · 2023Review
- The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance.Life science alliance · 2023Article
- Detection of Deregulated miRNAs in Childhood Epileptic Encephalopathies.Journal of molecular neuroscience : MN · 2022Article
- MiR-499a prevents astrocytes mediated inflammation in ischemic stroke by targeting PTEN.Non-coding RNA research · 2021Article
- miR-323a regulates ERBB4 and is involved in depression.Molecular psychiatry · 2021Article
- Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy.Molecular brain · 2021Article
- MicroRNA-210 Regulates Dendritic Morphology and Behavioural Flexibility in Mice.Molecular neurobiology · 2021Article
- Circulating microRNA: The Potential Novel Diagnostic Biomarkers to Predict Drug Resistance in Temporal Lobe Epilepsy, a Pilot Study.International journal of molecular sciences · 2021Article
- Identification of hsa-miR-1275 as a Novel Biomarker TargetingMolecular therapy. Methods & clinical development · 2020Article
- MicroRNAs as regulators of brain function and targets for treatment of epilepsy.Nature reviews. Neurology · 2020Review
- [Differential expression of miR-30a-5p in post stroke depression and bioinformatics analysis of the possible mechanism].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Extracellular Vesicles in the Forebrain Display Reduced miR-346 and miR-331-3p in a Rat Model of Chronic Temporal Lobe Epilepsy.Molecular neurobiology · 2020Article
- Epilepsy miRNA Profile Depends on the Age of Onset in Humans and Rats.Frontiers in neuroscience · 2020Article
- MicroRNAs as Immune Regulators of Inflammation in Children with Epilepsy.International journal of molecular and cellular medicine · 2020Article
- Article
- MicroRNA inhibition upregulates hippocampal A-type potassium current and reduces seizure frequency in a mouse model of epilepsy.Neurobiology of disease · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy affects around 50 million people worldwide, and in about 65% of patients, the etiology of disease is unknown. MicroRNAs are small non-coding RNAs that have been suggested to play a role in the pathophysiology of epilepsy. Here, we compared microRNA expression patterns in the hippocampus using two chronic models of epilepsy characterised by recurrent spontaneous seizures (pilocarpine and self-sustained status epilepticus (SSSE)) and an acute 6-Hz seizure model. The vast majority of microRNAs deregulated in the acute model exhibited increased expression with 146 microRNAs up-regulated within 6 h after a single seizure. In contrast, in the chronic models, the number of up-regulated microRNAs was similar to the number of down-regulated microRNAs. Three microRNAs-miR-142-5p, miR-331-3p and miR-30a-5p-were commonly deregulated in all three models. However, there is a clear overlap of differentially expressed microRNAs within the chronic models with 36 and 15 microRNAs co-regulated at 24 h and at 28 days following status epilepticus, respectively. Pathway analysis revealed that the altered microRNAs are associated with inflammation, innate immunity and cell cycle regulation. Taken together, the identified microRNAs and the pathways they modulate might represent candidates for novel molecular approaches for the treatment of patients with epilepsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.