ArticleFuture medicinal chemistry2014
Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery.
Article in Future medicinal chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Stereodivergent Construction ofJournal of the American Chemical Society · 2026Article
- Head-tail carboboration of multisubstituted alkenes enabled by chain recognition.Nature chemistry · 2025Article
- Newly isolated terpenoids (covering 2019-2024) from Aspergillus species and their potential for the discovery of novel antimicrobials.Natural products and bioprospecting · 2025Review
- Via Air or Rhizosphere: The Phytotoxicity ofPlants (Basel, Switzerland) · 2025Review
- Elicitor-driven enhancement of phenolic compounds in geranium callus cultures: phytochemical profiling via LC-MS/MS and biological activities.Frontiers in chemistry · 2025Article
- Efficient accumulation of new irregular monoterpene malonyl glucosides inFrontiers in plant science · 2025Article
- Standardizing Substrate Selection: A Strategy toward Unbiased Evaluation of Reaction Generality.ACS central science · 2024Article
- Green Copolymers and Nanocomposites from Myrcene and Limonene Using Algerian Nano-Clay as Nano-Reinforcing Filler.Polymers · 2022Article
- Article
- Total syntheses of strained polycyclic terpenes.Chemical communications (Cambridge, England) · 2022Review
- Modular terpene synthesis enabled by mild electrochemical couplings.Science (New York, N.Y.) · 2022Article
- In Vitro Anti-Inflammatory Activity of Essential Oil and β-Bisabolol Derived from Cotton Gin Trash.Molecules (Basel, Switzerland) · 2022Article
- Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.Biochemistry · 2021Article
- A Study of an 8-Aminoquinoline-Directed C(spThe Journal of organic chemistry · 2021Article
- Anti-protozoal activity of Thymol and a Thymol ester against Cryptosporidium parvum in cell culture.International journal for parasitology. Drugs and drug resistance · 2021Article
- Anti-Inflammatory Activity of Extracts and Pure Compounds Derived from Plants via Modulation of Signaling Pathways, Especially PI3K/AKT in Macrophages.International journal of molecular sciences · 2020Review
- Optimal Design of THEDES Based on Perillyl Alcohol and Ibuprofen.Pharmaceutics · 2020Article
- (R)-(+)-β-Citronellol and (S)-(-)-β-Citronellol in Combination with Amphotericin B against Candida Spp.International journal of molecular sciences · 2020Article
- Secondary Metabolites from Gorgonian Corals of the GenusMolecules (Basel, Switzerland) · 2019Review
- Identifying and engineering the ideal microbial terpenoid production host.Applied microbiology and biotechnology · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Terpenoids constitute a significant fraction of molecules produced by living organisms that have found use in medicine and other industries. Problems associated with their procurement and adaptation for human use can be solved using chemical synthesis, which is an increasingly economical option in the modern era of chemistry. This article documents, by way of individual case studies, strategies for reducing the time and cost of terpene synthesis for drug discovery. A major trend evident in recent syntheses is that complex terpenes are increasingly realistic starting points for both medicinal chemistry campaigns and large-scale syntheses, at least in the context of the academic laboratory, and this trend will likely penetrate the commercial sector in the near future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.