ArticleSpine2014
Specimen-specific nonlinear finite element modeling to predict vertebrae fracture loads after vertebroplasty.
Article in Spine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Hip position may be associated with susceptibility to Rommens type IIIa fragility fractures of the pelvis during lateral falls: a quantitative computed tomography-based finite element analysis.BMC musculoskeletal disorders · 2026Article
- Optimization of Bone Cement Stiffness in Metastatic Vertebral Augmentation: Balancing Strength Restoration and Stress Redistribution.Annals of biomedical engineering · 2026Article
- Comparative Finite Element Analysis of Denosumab and Bazedoxifene on Pedicle Screw Stability in Osteoporotic Spines.JOR spine · 2025Article
- Biomechanical effects of defect size and location on vertebral fracture.Journal of medical and biological engineering · 2025Article
- The potential effect of romosozumab on perioperative management for instrumentation surgery.JOR spine · 2024Article
- Quantitative Analysis of Stress-Stretch Curves in Canine Lumbar Vertebrae Using Modified Logistic Functions.Bioengineering (Basel, Switzerland) · 2024Article
- Simulating Knee-Stress Distribution Using a Computed Tomography-Based Finite Element Model: A Case Study.Journal of functional morphology and kinesiology · 2023Article
- Toward an artificial intelligence-assisted framework for reconstructing the digital twin of vertebra and predicting its fracture response.International journal for numerical methods in biomedical engineering · 2022Article
- A Three-Dimensional Cement Quantification Method for Decision Prediction of Vertebral Recompression after Vertebroplasty.Computational and mathematical methods in medicine · 2022Article
- Single-level subject-specific finite element model can predict fracture outcomes in three-level spine segments under different loading rates.Computers in biology and medicine · 2021Article
- Impact of Screw Diameter and Length on Pedicle Screw Fixation Strength in Osteoporotic Vertebrae: A Finite Element Analysis.Asian spine journal · 2021Article
- CT-based structural analyses of vertebral fractures with polymeric augmentation: A study of cadaveric three-level spine segments.Computers in biology and medicine · 2021Article
- A Simulation Case Study of Knee Joint Compressive Stress during the Stance Phase in Severe Knee Osteoarthritis Using Finite Element Method.Medicina (Kaunas, Lithuania) · 2021Article
- A Multiscale Finite Element Analysis of Balloon Kyphoplasty to Investigate the Risk of Bone-Cement Separation In Vivo.International journal of spine surgery · 2021Article
- The effect of denosumab on pedicle screw fixation: a prospective 2-year longitudinal study using finite element analysis.Journal of orthopaedic surgery and research · 2021Article
- Towards a validated patient-specific computational modeling framework to identify failure regions in traditional growing rods in patients with early onset scoliosis.North American Spine Society journal · 2021Article
- Prediction of Risk Factors for Pathological Fracture After Bone Tumor Biopsy Using Finite Element Analysis.Cancer management and research · 2021Article
- Development of a Knee Joint CT-FEM Model in Load Response of the Stance Phase During Walking Using Muscle Exertion, Motion Analysis, and Ground Reaction Force Data.Medicina (Kaunas, Lithuania) · 2020Article
- Mechanical testing setups affect spine segment fracture outcomes.Journal of the mechanical behavior of biomedical materials · 2019Article
- Case-specific non-linear finite element models to predict failure behavior in two functional spinal units.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
STUDY
designVertebral fracture load and stiffness from a metastatic vertebral defect model were predicted using nonlinear finite element models (FEM) and validated experimentally.
objectiveThe study objective was to develop and validate an FEM-based tool for predicting polymer-augmented lytic vertebral fracture load and stiffness and the influence of metastatic filling materials. SUMMARY OF BACKGROUND DATA: Percutaneous vertebroplasty has the potential to reduce vertebral fracture risk affected with lytic metastases by providing mechanical stabilization. However, it has been shown that the mismatch in mechanical properties between poly(methyl-methacrylate) (PMMA) and bone induces secondary fractures and intervertebral disc degeneration. A biodegradable copolymer, poly(propylene fumarate-co-caprolactone) (P(PF-co-CL)), has been shown to possess the appropriate mechanical properties for bone defect repair.
methodsSimulated metastatic lytic defects were created in 40 cadaveric vertebral bodies, which were randomized into 4 groups: intact vertebral body (intact), simulated defect without treatment (negative), defect treated with P(PF-co-CL) (copolymer), and defect treated with PMMA (PMMA). Spines were imaged with quantitative computed tomography (QCT), and QCT/FEM-subject-specific, nonlinear models were created. Predicted fracture loads and stiffness were identified and compared with experimentally measured values using Pearson correlation analysis and paired t test.
resultsThere was no significant difference between the measured and predicted fracture loads and stiffness for each group. Predicted fracture loads were larger for PMMA augmentation (3960 N [1371 N]) than that for the copolymer, negative and intact groups (3484 N [1497 N], 3237 N [1744 N], and 1747 N [702 N]). A similar trend was observed in the predicted stiffness. Moreover, predicted and experimental fracture loads were strongly correlated (R=0.78), whereas stiffness showed moderate correlation (R=0.39).
conclusionQCT/FEM was successful for predicting fracture loads of metastatic, polymer-augmented vertebral bodies. Overall, we have demonstrated that QCT/FEM may be a useful tool for predicting in situ vertebral fracture load resulting from vertebroplasty. LEVEL OF EVIDENCE: N/A.
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