ArticlePlant physiology2014
Indaziflam herbicidal action: a potent cellulose biosynthesis inhibitor.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Practice in Nursery Weed Control-Review and Meta-Analysis.Frontiers in plant science · 2021Pooled it
- Ligand-Baited Proteomics Reveals Vesicle Trafficking Proteins as Putative Site of Action of Indaziflam.Journal of agricultural and food chemistry · 2026Article
- Ubiquitination of the ribosomal-like domain of UBIQUITIN6 contributes to cell wall stress responses in Arabidopsis.The Plant cell · 2026Article
- A fungal natural product that inhibits plant cellulose biosynthesis by disrupting cellulose synthase complexes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Poa annua becomes the first weed to evolve resistance to indaziflam applied preemergence and early-postemergence.Pest management science · 2026Article
- Rye sprout as a host for the rapid transient production of a recombinant protein using a geminivirus DNA-containing expression vector.Plant biotechnology (Tokyo, Japan) · 2025Article
- Discovery of new PSII inhibitors: systematic investigation for herbicidal activity screening, properties, and mode of action.Pest management science · 2025Article
- A cellulose synthesis inhibitor affects cellulose synthase complex secretion and cortical microtubule dynamics.Plant physiology · 2024Article
- Discovery and Characterization of Fluopipamine, a Putative Cellulose Synthase 1 Antagonist withinJournal of agricultural and food chemistry · 2024Article
- Plant and soil microbial composition legacies following indaziflam herbicide treatment.Frontiers in microbiology · 2024Article
- Breaking-Down Barriers: Proposal of Using Cellulose Biosynthesis Inhibitors and Cellulase Enzyme as a Novel Treatment Modality for Vision Threatening Pythium Insidiosum Keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Increasing cassava root yield on farmers' fields in Nigeria through appropriate weed management.Crop protection (Guildford, Surrey) · 2021Article
- Fluorescent labeling of the root cap cells with the bioactive NBD-S chemical probe based on the cellulose biosynthesis inhibition herbicides.Biochemistry and biophysics reports · 2021Article
- Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibit Cellulose Biosynthesis.The Plant cell · 2020Article
- Comparative Transcriptome Analysis of Two Contrasting Soybean Varieties in Response to Aluminum Toxicity.International journal of molecular sciences · 2020Article
- Plant cell wall integrity maintenance in model plants and crop species-relevant cell wall components and underlying guiding principles.Cellular and molecular life sciences : CMLS · 2020Review
- Genome Editing-Based Engineering of CESA3 Dual Cellulose-Inhibitor-Resistant Plants.Plant physiology · 2019Article
- Arabidopsis thaliana plants lacking the ARP2/3 complex show defects in cell wall assembly and auxin distribution.Annals of botany · 2018Article
- Mitochondrial Defects Confer Tolerance against Cellulose Deficiency.The Plant cell · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellulose biosynthesis is a common feature of land plants. Therefore, cellulose biosynthesis inhibitors (CBIs) have a potentially broad-acting herbicidal mode of action and are also useful tools in decoding fundamental aspects of cellulose biosynthesis. Here, we characterize the herbicide indaziflam as a CBI and provide insight into its inhibitory mechanism. Indaziflam-treated seedlings exhibited the CBI-like symptomologies of radial swelling and ectopic lignification. Furthermore, indaziflam inhibited the production of cellulose within <1 h of treatment and in a dose-dependent manner. Unlike the CBI isoxaben, indaziflam had strong CBI activity in both a monocotylonous plant (Poa annua) and a dicotyledonous plant (Arabidopsis [Arabidopsis thaliana]). Arabidopsis mutants resistant to known CBIs isoxaben or quinoxyphen were not cross resistant to indaziflam, suggesting a different molecular target for indaziflam. To explore this further, we monitored the distribution and mobility of fluorescently labeled CELLULOSE SYNTHASE A (CESA) proteins in living cells of Arabidopsis during indaziflam exposure. Indaziflam caused a reduction in the velocity of YELLOW FLUORESCENT PROTEIN:CESA6 particles at the plasma membrane focal plane compared with controls. Microtubule morphology and motility were not altered after indaziflam treatment. In the hypocotyl expansion zone, indaziflam caused an atypical increase in the density of plasma membrane-localized CESA particles. Interestingly, this was accompanied by a cellulose synthase interacting1-independent reduction in the normal coincidence rate between microtubules and CESA particles. As a CBI, for which there is little evidence of evolved weed resistance, indaziflam represents an important addition to the action mechanisms available for weed management.
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