ArticleMolecular genetics & genomic medicine2014
Telomere length, family history, and paternal age in schizophrenia.
Article in Molecular genetics & genomic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Relation ofClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Article
- Epigenetic clocks in relapse after a first episode of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Telomere Length as a Marker of Suicidal Risk in Schizophrenia.Consortium psychiatricum · 2022Article
- Telomere length and early trauma in schizophrenia.Schizophrenia research · 2018Article
- Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions.Schizophrenia bulletin · 2018Review
- No evidence for parental age effects on offspring leukocyte telomere length in free-living Soay sheep.Scientific reports · 2017Article
- Longer Telomere Length of T lymphocytes in Patients with Early and Chronic Psychosis.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- Parental age effects on odor sensitivity in healthy subjects and schizophrenia patients.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- Association of telomere length and mitochondrial DNA copy number with risperidone treatment response in first-episode antipsychotic-naïve schizophrenia.Scientific reports · 2015Article
- Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder.Neurotoxicity research · 2015Review
- Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.Neuroscience and biobehavioral reviews · 2015Review
- Paternal age and mental health of offspring.Fertility and sterility · 2015Review
- Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia.Neuropsychiatric disease and treatment · 2015Article
- Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy?Oxidative medicine and cellular longevity · 2015Review
- Low vitamin D levels predict clinical features of schizophrenia.Schizophrenia research · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Leukocyte telomere length (LTL) is longer in association with advanced paternal age, but this association has not been examined along with family history (FH) in schizophrenia. LTL was measured by PCR and compared across cases and controls as part of a study to examine the characteristics of paternal age related schizophrenia. The 53 schizophrenia cases had similar mean LTL as 20 controls, although cases were significantly older than controls and overwhelmingly smoked cigarettes. Multivariate analyses showed that a FH of schizophrenia was associated with longer LTL in both male and female cases. Later paternal age was also related to longer LTL in male cases, but with shorter LTL in female cases. Male cases with older fathers and a FH had the longest LTL. The genetic architecture associated with a familial risk for schizophrenia may include pathways that lengthen LTL. Paternal aging conferred an additional increase in LTL lengthening in male cases, but reduced LTL in female cases. The gender difference in LTL for paternal aging is consistent with the severe illness features reported for female cases with older fathers and could implicate epigenetic alterations in the paternal X chromosomal region with advanced paternal age in association with the risk for schizophrenia.
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