ArticleNorth American journal of medical sciences2014
Cardiovascular risks in prediabetes: preliminary data on "vasculopathy triad".
Article in North American journal of medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Assessment of Changes in Glycaemic Control and Blood Viscosity Determinants: Does Glycaemia Impact on Haematocrit, Proteinaemia or Dyslipidaemia?Medical sciences (Basel, Switzerland) · 2025Article
- Blood Viscosity Changes in Diabetes Mellitus: A 20-Year Bibliometric Review and Future Directions.Cureus · 2024Review
- Global coagulation assays in patients with diabetes mellitus.Research and practice in thrombosis and haemostasis · 2021Article
- Autophagy in Diabetes Pathophysiology: Oxidative Damage Screening as Potential for Therapeutic Management by Clinical Laboratory Methods.Frontiers in cell and developmental biology · 2021Article
- Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women.International journal of medical sciences · 2016Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubclinical cardiovascular disease is inherent in complications of diabetes mellitus. It occurs before the obvert manifestation of cardiovascular disease complication in diabetes, and involves vasculopathy triad or three major vascular events comprising stasis, endothelial dysfunction, and atherothrombosis.
aimThis study was to examine evidence of vasculopathy triad in prediabetes, biomarkers of stasis, endothelial dysfunction, and atherothrombosis in prediabetes were compared with apparently healthy group. MATERIALS AND
methodsEighty-one participants with results for plasma D-dimer, homocysteine, and whole blood viscosity were selected from a research database. The participants consisted of control (n = 44) and prediabetes (n = 37) based on clinical history and laboratory results.
resultsMultivariate analysis shows a significantly higher level of vasculopathy in prediabetes than in the control group (P > 0.0001). Blood viscosity (P < 0.04) and homocysteine (P < 0.03) are significantly higher in prediabetes than in controls. Average levels for plasma D-dimer are also higher in prediabetes than in control, but not statistically significant in this particular analysis.
conclusionThis study suggests a novel application of known idea, vasculopathy triad that could be used for assessment of subclinical cardiovascular disease in prediabetes.
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