Evidence map›Paper›PMID 25077069›Full record

ArticleFrontiers in oncology2014

Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas.

Tiago Santos, Xin Fang, Meng-Tse Chen, Weijun Wang, Raquel Ferreira, Niyati Jhaveri, Martin Gundersen, Chongwu Zhou, Paul Pagnini, Florence M Hofman and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Hyperthermia treatment advances for brain tumors.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020
    Review
  9. Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers.International journal of nanomedicine · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Bionanotechnology and the future of glioma.Surgical neurology international · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Tiago SantosDepartment of Pathology, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA ; University of Coimbra , Coimbra , Portugal.
Xin FangDepartment of Electrical Engineering, Viterbi School of Engineering, University of Southern California , Los Angeles, CA , USA ; Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California , Los Angeles, CA , USA.
Meng-Tse ChenDepartment of Electrical Engineering, Viterbi School of Engineering, University of Southern California , Los Angeles, CA , USA ; Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California , Los Angeles, CA , USA.
Weijun WangDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.
Raquel FerreiraDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.
Niyati JhaveriDepartment of Pathology, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.
Martin GundersenDepartment of Electrical Engineering, Viterbi School of Engineering, University of Southern California , Los Angeles, CA , USA ; Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California , Los Angeles, CA , USA.
Chongwu ZhouDepartment of Electrical Engineering, Viterbi School of Engineering, University of Southern California , Los Angeles, CA , USA ; Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California , Los Angeles, CA , USA.
Paul PagniniDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.
Florence M HofmanDepartment of Pathology, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA ; Department of Neurological Surgery, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.
Thomas C ChenDepartment of Pathology, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA ; Department of Neurological Surgery, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.
University of Southern California · USNeurological Surgery · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective was to use carbon nanotubes (CNT) coupled with near-infrared radiation (NIR) to induce hyperthermia as a novel non-ionizing radiation treatment for primary brain tumors, glioblastoma multiforme (GBM). In this study, we report the therapeutic potential of hyperthermia-induced thermal ablation using the sequential administration of carbon nanotubes (CNT) and NIR. In vitro studies were performed using glioma tumor cell lines (U251, U87, LN229, T98G). Glioma cells were incubated with CNTs for 24 h followed by exposure to NIR for 10 min. Glioma cells preferentially internalized CNTs, which upon NIR exposure, generated heat, causing necrotic cell death. There were minimal effects to normal cells, which correlate to their minimal uptake of CNTs. Furthermore, this protocol caused cell death to glioma cancer stem cells, and drug-resistant as well as drug-sensitive glioma cells. This sequential hyperthermia therapy was effective in vivo in the rodent tumor model resulting in tumor shrinkage and no recurrence after only one treatment. In conclusion, this sequence of selective CNT administration followed by NIR activation provides a new approach to the treatment of glioma, particularly drug-resistant gliomas.

Indexed as

carbon nanotubesglioblastoma multiformegliomahyperthermianear-infrared radiation

Identifiers

PMID25077069
PMCPMC4097104
OpenAlexW2076772067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.