ArticleSpringerPlus2014
High phosphoserine in sepsis: panel of clinical and plasma amino acid correlations.
Article in SpringerPlus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- UHPLC/MS-Based Untargeted Metabolomics Reveals Metabolic Characteristics of Clinical Strain ofMicroorganisms · 2023Article
- Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response.Metabolites · 2022Review
- Title NMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection.Scientific reports · 2020Article
- Largely reduced grid densities in a vibrational self-consistent field treatment do not significantly impact the resultingwavenumbers.Molecules (Basel, Switzerland) · 2014Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The determination of plasma phosphoserine concentration in sepsis is uncommon, and the clinical and metabolic correlations of abnormally high phosphoserine are basically unknown. We analyzed 430 determinations of phosphoserine, other amino acid (AA) levels and ancillary variables obtained in 18 septic patients, in order to assess the biochemical and clinical correlations of changes in phosphoserine. Phosphoserine ranged between 5 and 55 micromol/L (n.v. < 12). Increasing phosphoserine was associated with higher severity of illness and death, and its best AA correlates were increasing cystathionine, 3-methylhistidine, histidine, hydroxyproline and tyrosine (r > 0.65, p < 0.001 for all). High phosphoserine seemed to cumulatively reflect kidney and liver dysfunction and enhanced proteolysis. As a collateral finding, 3-methylhistidine (a best correlate of phosphoserine) was also inversely related to nutritional AA dose (p < 0.001). These data suggest that in septic patients the determination of plasma phosphoserine may provide useful information on severity of septic illness and prognosis. The observed correlations also indirectly evidenced an impact of nutritional AA dose in moderating proteolysis.
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Registered trials
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