Evidence map›Paper›PMID 25076874›Full record

ReviewFrontiers in neural circuits2014

Treatment of amblyopia in the adult: insights from a new rodent model of visual perceptual learning.

Joyce Bonaccorsi, Nicoletta Berardi, Alessandro Sale

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  7. Review
  8. Low availability of cholineFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  9. Article
  10. Review
  11. Review
  12. Critical periods in amblyopia.Visual neuroscience · 2018
    Review
  13. Article
  14. Article
  15. Article
  16. Active training for amblyopia in adult rodents.Frontiers in behavioral neuroscience · 2015
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joyce BonaccorsiDepartment of Medicine, Institute of Neuroscience CNR, National Research Council (CNR) Pisa, Italy.
Nicoletta BerardiDepartment of Medicine, Institute of Neuroscience CNR, National Research Council (CNR) Pisa, Italy ; Department of Psychology, Florence University Florence, Italy.
Alessandro SaleDepartment of Medicine, Institute of Neuroscience CNR, National Research Council (CNR) Pisa, Italy.
National Research Council · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amblyopia is the most common form of impairment of visual function affecting one eye, with a prevalence of about 1-5% of the total world population. Amblyopia usually derives from conditions of early functional imbalance between the two eyes, owing to anisometropia, strabismus, or congenital cataract, and results in a pronounced reduction of visual acuity and severe deficits in contrast sensitivity and stereopsis. It is widely accepted that, due to a lack of sufficient plasticity in the adult brain, amblyopia becomes untreatable after the closure of the critical period in the primary visual cortex. However, recent results obtained both in animal models and in clinical trials have challenged this view, unmasking a previously unsuspected potential for promoting recovery even in adulthood. In this context, non invasive procedures based on visual perceptual learning, i.e., the improvement in visual performance on a variety of simple visual tasks following practice, emerge as particularly promising to rescue discrimination abilities in adult amblyopic subjects. This review will survey recent work regarding the impact of visual perceptual learning on amblyopia, with a special focus on a new experimental model of perceptual learning in the amblyopic rat.

Indexed as

AmblyopiaAnimalsDisease Models, AnimalHumansLearningRatsSensation DisordersVisual AcuityVisual Perceptionamblyopiaenvironmental enrichmentGABAergic inhibitionperceptual learningvisual acuity

Identifiers

PMID25076874
PMCPMC4100600
OpenAlexW2047304118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.