ReviewArchives of pathology & laboratory medicine2014
Orbital granulomatosis with polyangiitis (Wegener granulomatosis): clinical and pathologic findings.
Review in Archives of pathology & laboratory medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 71 citations in OpenAlex.
- Orbital pseudotumor and skull base infiltration as the sole manifestation of granulomatosis with polyangiitis.Reumatologia · 2026Article
- The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment.Ophthalmology and therapy · 2025Review
- Management of Orbital Granulomatous Polyangiitis Presenting with Lacrimal Gland Involvement: Treatment of Subsequent Peripheral Ulcerative Keratitis, Anterior Uveitis, and Exudative Retinal Detachment in a Challenging Case.Turkish journal of ophthalmology · 2024Article
- Orbital Masses in Granulomatosis with Polyangiitis: A Call for Clinical Vigilance.European journal of rheumatology · 2024Article
- Recurrent Coronary Vasospasm in a 50-Year-Old Woman with Granulomatous Polyangiitis: A Case Report.Journal of inflammation research · 2024Article
- Autoimmune markers in screening for orbital inflammatory disease.Eye (London, England) · 2023Article
- Autoimmune disease of head and neck, imaging, and clinical review.The neuroradiology journal · 2022Review
- Utility of Optical Coherence Tomography Angiography (OCTA) in Granulomatosis With Polyangiitis.Cureus · 2022Article
- Pediatric uveitis: Role of the pediatrician.Frontiers in pediatrics · 2022Review
- Atypical Granulomatosis with Polyangiitis Presenting with Meibomitis, Scleritis, Uveitis and Papillary Bladder Tumor: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2021Article
- Sustained clinical remission under infliximab/rituximab combination therapy in a patient with granulomatosis with polyangiitis.Auto- immunity highlights · 2021Article
- Radiotherapy of granulomatosis with polyangiitis occurring in the eyelid: A case report and literature review.Medicine · 2021Review
- Rare Presentation of Severely Limited Granulomatosis With Polyangiitis Manifesting With Orbital Wall Destruction: Literature Review and Case Report.Archives of rheumatology · 2020Article
- Etiologies of Proptosis: A review.Internal medicine review (Washington, D.C. : Online) · 2020Article
- Therapeutic challenges in the treatment of systemic inflammatory disease in pregnancy.Obstetric medicine · 2019Article
- Orbital Vasculitides-Differential Diagnosis.Current rheumatology reports · 2019Review
- Ocular Manifestations of Granulomatosis with Polyangiitis: A Review of the Literature.Ophthalmology and therapy · 2019Review
- Clinical significance of ocular manifestations in granulomatosis with polyangiitis: association with sinonasal involvement and damage.Rheumatology international · 2019Article
- Resolved heart tamponade and controlled exophthalmos, facial pain and diabetes insipidus due to Erdheim-Chester disease.BMJ case reports · 2018Article
- Successful reconstruction of an ocular defect resulting from granulomatosis with polyangiitis, following treatment with rituximab.American journal of ophthalmology case reports · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The pathology of granulomatosis with polyangiitis (GPA), formerly Wegener granulomatosis, typically features a granulomatous and sometimes necrotizing vasculitis targeting the respiratory tract and kidneys. However, orbital involvement occurs in up to 60% of patients and is frequently the first or only clinical presentation in patients with systemic or limited forms of GPA. Orbital GPA can cause significant morbidity and potentially lead to complete loss of vision and permanent facial deformity. Fortunately, GPA is highly responsive to medical treatment with corticosteroids combined with cyclophosphamide or, more recently, rituximab. Therefore, it is imperative for this disease to be accurately diagnosed on orbital biopsy and distinguished from other histologically similar orbital lesions. Herein, we review the clinical and pathologic findings of orbital GPA, focusing on the differentiation of this disease from other inflammatory orbital lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.