Evidence map›Paper›PMID 25076227›Full record

Trial reportOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2015

Power reflectance as a screening tool for the diagnosis of superior semicircular canal dehiscence.

Gabrielle R Merchant, Christof Röösli, Marlien E F Niesten, Mohamad A Hamade, Daniel J Lee, Melissa L McKinnon, Cagatay H Ulku, John J Rosowski, Saumil N Merchant, Hideko Heidi Nakajima

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

  1. Observational
  2. Observational
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Review
  9. Article
  10. On the calculation of reflectance in non-uniform ear canals.The Journal of the Acoustical Society of America · 2019
    Article
  11. Article
  12. A comparison of ear-canal-reflectance measurement methods in an ear simulator.The Journal of the Acoustical Society of America · 2019
    Article
  13. Article
  14. Article
  15. Reflectance measurement validation using acoustic horns.The Journal of the Acoustical Society of America · 2015
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Gabrielle R Merchant*Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.; ‡Speech and Hearing Bioscience and Technology Program, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, U.S.A.; §Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, U.S.A.; ∥Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland; ¶Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Center, Utrecht, the Netherlands; and #Department of Otorhinolaryngology - Head and Neck Surgery, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
Christof Röösli
Marlien E F Niesten
Mohamad A Hamade
Daniel J Lee
Melissa L McKinnon
Cagatay H Ulku
John J Rosowski
Saumil N Merchant
Hideko Heidi Nakajima
Harvard University · USNecmettin Erbakan University · TRUniversity Hospital of Zurich · CHUniversity Medical Center Utrecht · NL

Funding

TRAINING FOR SPEECH AND HEARING SCIENCEST32DC000038 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Gwenaelle S Geleoc · 1992 to 2026
$21.8M
Middle-ear Mechanics in Normal and Pathological EarsR01DC004798 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI NAKAJIMA, HIDEKO HEIDI · 2001 to 2016
$4.9M
Mechanics of Human Middle & Inner Ear: Basic Science & Clinical ApplicationR01DC013303 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI NAKAJIMA, HIDEKO HEIDI · 2013 to 2024
$4.5M
Investigations of Human Auditory MechanicsR03DC011158 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI NAKAJIMA, HIDEKO HEIDI · 2010 to 2012
$492k
NIDCD NIH HHS R01 DC004798NIDCD NIH HHS R01DC004798NIDCD NIH HHS R01 DC013303NIDCD NIH HHS R03 DC011158NIDCD NIH HHS R03DC011158NIDCD NIH HHS T32 DC000038
6 · The paper itself

Abstract

hypothesisPower reflectance (PR) measurements in ears with superior canal dehiscence (SCD) have a characteristic pattern, the detection of which can assist in diagnosis.

backgroundThe aim of this study was to determine whether PR coupled with a novel detection algorithm can perform well as a fast, noninvasive, and easy screening test for SCD. The screening test aimed to determine whether patients with various vestibular and/or auditory symptom(s) should be further considered for more expensive and invasive tests that better define the diagnosis of SCD (and other third-window lesions).

methodsPower reflectance was measured in patients diagnosed with SCD by high-resolution computed tomography. The study included 40 ears from 32 patients with varying symptoms (e.g., with and without conductive hearing loss, vestibular symptoms, and abnormal auditory sensations).

resultsPower reflectance results were compared to previously published norms and showed that SCD is commonly associated with a PR notch near 1 kHz. An analysis algorithm was designed to detect such notches and to quantify their incidence in affected and normal ears. Various notch detection thresholds yielded sensitivities of 80% to 93%, specificities of 69% to 72%, negative predictive values of 84% to 93%, and a positive predictive value of 67%.

conclusionThis study shows evidence that PR measurements together with the proposed notch-detecting algorithm can be used to quickly and effectively screen patients for third-window lesions such as SCD in the early stages of a diagnostic workup.

Indexed as

AlgorithmsDiagnostic Techniques, OtologicalAdultAgedFemaleHumansLabyrinth DiseasesMaleMiddle AgedPressureSemicircular CanalsTomography, X-Ray Computed

Identifiers

PMID25076227
PMCPMC4267998
OpenAlexW2321536595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.