ArticleBrazilian journal of physical therapy
Effect of low-level laser therapy on the modulation of the mitochondrial activity of macrophages.
Article in Brazilian journal of physical therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Photobiomodulation Therapy in Chronic Autoimmune Thyroiditis: A Systematic Review of Molecular Mechanisms and Clinical Applications.International journal of molecular sciences · 2026Pooled it
- Pooled it
- Review of light parameters and photobiomodulation efficacy: dive into complexity.Journal of biomedical optics · 2018Pooled it
- Adjunctive low-level laser therapy in periodontal treatment - A randomized clinical split-mouth trial.Clinical oral investigations · 2025Trial
- Low-level laser therapy, piezocision, or their combination vs. conventional treatment for orthodontic tooth movement : A hierarchical 6-arm split-mouth randomized clinical trial.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2024Trial
- An in vitro method to test the safety and efficacy of low-level laser therapy (LLLT) in the healing of a canine skin model.BMC veterinary research · 2016Trial
- Effects of photobiomodulation, alone or combined with dexamethasone, on cellular metabolic activity and inflammatory markers in LPS/IFN-γ-stimulated J774 macrophages.Lasers in medical science · 2026Article
- Evaluation of laser-photobiomodulation different irradiation parameters on macrophages (RAW 264.7) inflammatory mediators' production.Lasers in medical science · 2025Article
- In Vitro Effects of Low-Level Laser Therapy on the Viability and Secretory Activity of Resting Macrophages.Biomedicines · 2025Article
- Photobiomodulation therapy.JADA foundational science · 2025Review
- The Mechanisms and Efficacy of Photobiomodulation Therapy for Arthritis: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Efficacy of Combined Photobiomodulation Therapy with Supplements versus Supplements alone in Restoring Thyroid Gland Homeostasis in Hashimoto Thyroiditis: A Clinical Feasibility Parallel Trial with 6-Months Follow-Up.Journal of personalized medicine · 2023Article
- The Effects and Mechanisms of PBM Therapy in Accelerating Orthodontic Tooth Movement.Biomolecules · 2023Review
- The Novel Digital Therapeutics Sensor and Algorithm for Pressure Ulcer Care Based on Tissue Impedance.Sensors (Basel, Switzerland) · 2023Article
- Low-power laser in increasing doses improve wound healing process in rats.Lasers in medical science · 2023Article
- Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer's disease.Alzheimer's research & therapy · 2022Article
- Effect of photobiomodulation on mitochondrial dynamics in peripheral nervous system in streptozotocin-induced type 1 diabetes in rats.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021Article
- Participation of the Immune System and Hedgehog Signaling in Neoangiogenesis Under Laser Photobiomodulation.Journal of lasers in medical sciences · 2019Article
- Synergistic effects of Combined Therapy: nonfocused ultrasound plus Aussie current for noninvasive body contouring.Clinical, cosmetic and investigational dermatology · 2018Article
- Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.Molecular neurobiology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMacrophages play a major role among the inflammatory cells that invade muscle tissue following an injury. Low-level laser therapy (LLLT) has long been used in clinical practice to accelerate the muscle repair process. However, little is known regarding its effect on macrophages.
objectiveThis study evaluated the effect of LLLT on the mitochondrial activity (MA) of macrophages.
methodJ774 macrophages were treated with lipopolysaccharide (LPS) and interferon - gamma (IFN-γ) (activation) for 24 h to simulate an inflammatory process, then irradiated with LLLT using two sets of parameters (780 nm; 70 mW; 3 J/cm2 and 660 nm; 15 mW; 7.5 J/cm2). Non-activated/non-irradiated cells composed the control group. MA was evaluated by the cell mitochondrial activity (MTT) assay (after 1, 3 and 5 days) in three independent experiments. The data were analyzed statistically.
resultsAfter 1 day of culture, activated and 780 nm irradiated macrophages showed lower MA than activated macrophages, but activated and 660 nm irradiated macrophages showed MA similar to activated cells. After 3 days, activated and irradiated (660 nm and 780 nm) macrophages showed greater MA than activated macrophages, and after 5 days, the activated and irradiated (660 nm and 780 nm) macrophages showed similar MA to the activated macrophages.
conclusionsThese results show that 660 nm and 780 nm LLLT can modulate the cellular activation status of macrophages in inflammation, highlighting the importance of this resource and of the correct determination of its parameters in the repair process of skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.