ArticlePloS one2014
Phenotype refinement strengthens the association of AHR and CYP1A1 genotype with caffeine consumption.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Genetic susceptibility to caffeine intake and metabolism: a systematic review.Journal of translational medicine · 2024Pooled it
- Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study.European journal of epidemiology · 2022Pooled it
- GWAS of habitual coffee consumption reveals a sex difference in the genetic effect of the 12q24 locus in the Japanese population.BMC genetics · 2019Pooled it
- Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review.Nutrients · 2018Pooled it
- Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants.Scientific reports · 2018Pooled it
- Coffee consumption and cardiometabolic health: a comprehensive review of the evidence.GeroScience · 2024Review
- Dietary inflammatory index, genetic susceptibility and risk of incident dementia: a prospective cohort study from UK biobank.Journal of neurology · 2024Article
- Association of coffee and caffeine consumption with risk and prognosis of endometrial cancer and its subgroups: a Mendelian randomization.Frontiers in nutrition · 2023Article
- Genetic Variations on Redox Control in Cardiometabolic Diseases: The Role of Nrf2.Antioxidants (Basel, Switzerland) · 2022Review
- Causal relationship from coffee consumption to diseases and mortality: a review of observational and Mendelian randomization studies including cardiometabolic diseases, cancer, gallstones and other diseases.European journal of nutrition · 2022Review
- Coffee and caffeine consumption and risk of renal cell carcinoma: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- Associations of Blood Caffeine and Genetically Predicted Coffee Consumption with Anthropometric Measures of Obesity: A Two Sample Mendelian Randomization Study.The journal of nutrition, health & aging · 2022Article
- Article
- Paving the Way to Precision Nutrition Through Metabolomics.Frontiers in nutrition · 2019Review
- Genetic determinants of beverage consumption: Implications for nutrition and health.Advances in food and nutrition research · 2019Review
- Review
- Biases Inherent in Studies of Coffee Consumption in Early Pregnancy and the Risks of Subsequent Events.Nutrients · 2018Review
- Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.International journal of epidemiology · 2018Article
- A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study.Scientific reports · 2018Article
- Associations of coffee genetic risk scores with consumption of coffee, tea and other beverages in the UK Biobank.Addiction (Abingdon, England) · 2018Observational
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Two genetic loci, one in the cytochrome P450 1A1 (CYP1A1) and 1A2 (CYP1A2) gene region (rs2472297) and one near the aryl-hydrocarbon receptor (AHR) gene (rs6968865), have been associated with habitual caffeine consumption. We sought to establish whether a more refined and comprehensive assessment of caffeine consumption would provide stronger evidence of association, and whether a combined allelic score comprising these two variants would further strengthen the association. We used data from between 4,460 and 7,520 women in the Avon Longitudinal Study of Parents and Children, a longitudinal birth cohort based in the United Kingdom. Self-report data on coffee, tea and cola consumption (including consumption of decaffeinated drinks) were available at multiple time points. Both genotypes were individually associated with total caffeine consumption, and with coffee and tea consumption. There was no association with cola consumption, possibly due to low levels of consumption in this sample. There was also no association with measures of decaffeinated drink consumption, indicating that the observed association is most likely mediated via caffeine. The association was strengthened when a combined allelic score was used, accounting for up to 1.28% of phenotypic variance. This was not associated with potential confounders of observational association. A combined allelic score accounts for sufficient phenotypic variance in caffeine consumption that this may be useful in Mendelian randomization studies. Future studies may therefore be able to use this combined allelic score to explore causal effects of habitual caffeine consumption on health outcomes.
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