ArticleIET systems biology2014
Cell commitment motif composed of progenitor-specific transcription factors and mutual-inhibition regulation.
Article in IET systems biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Simple mutual-inhibition networks are frequently occurring motifs in transcriptional regulatory networks for cell lineage commitment. Stable attractors represent cell commitment states. However, how progenitor-specific transcription factors stabilise progenitor cells and commit them to different cell fates remains unexplained. In this study, the authors represent the cell commitment motifs composed of mutual-inhibition regulation and progenitor-specific transcription factors, and develop associated mathematical model to understand how specific cell fate decisions are made. Bifurcation analysis and numerical simulation show that the model could exhibit multiple stable steady states corresponding to progenitor and committed cell states. The transitions between different cell states correspond to different commitment processes. Furthermore, the authors demonstrate that different commitment patterns, for example, haematopoietic and neural fate decisions fall within the scope of proposed framework.
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