ArticleThe Journal of cell biology1989
Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 97 citations in OpenAlex.
- Bacillus anthracis edema toxin impairs neutrophil actin-based motility.Infection and immunity · 2009Article
- p53-cofactor JMY is a multifunctional actin nucleation factor.Nature cell biology · 2009Article
- Latrunculin B has different effects on pollen germination and tube growth.The Plant cell · 1999Article
- Integrin-mediated signals regulated by members of the rho family of GTPases.The Journal of cell biology · 1998Article
- Insulin induces tyrosine dephosphorylation of a 92 kDA protein in suspended monocytes.Journal of endocrinological investigation · 1998Article
- Role of gelsolin in actin depolymerization of adherent human neutrophils.Molecular biology of the cell · 1997Article
- A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)The Journal of experimental medicine · 1996Article
- A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility.The Journal of cell biology · 1996Article
- Free peripheral sulfhydryl groups, CD11/CD18 integrins, and calcium are required in the cadmium and nickel enhancement of human-polymorphonuclear leukocyte adherence.Archives of environmental contamination and toxicology · 1996Article
- Modulation of the adherence of human polymorphonuclear leukocytes by cadmium and nickel: sexual differences.Archives of environmental contamination and toxicology · 1995Article
- Mechanically stimulated cytoskeleton rearrangement and cortical contraction in human neutrophils.Biophysical journal · 1995Article
- Polymerization of actin in RBL-2H3 cells can be triggered through either the IgE receptor or the adenosine receptor but different signaling pathways are used.Molecular biology of the cell · 1994Article
- Beta 2 integrin engagement triggers actin polymerization and phosphatidylinositol trisphosphate formation in non-adherent human neutrophils.The Journal of cell biology · 1993Article
- Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ.The Journal of cell biology · 1993Article
- Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor.The Journal of cell biology · 1993Article
- Cytosolic free Ca2+ signals in single adherent human neutrophils: generation and functional role.European journal of pediatrics · 1993Review
- Micromanipulation of adhesion of phorbol 12-myristate-13-acetate-stimulated T lymphocytes to planar membranes containing intercellular adhesion molecule-1.Biophysical journal · 1992Article
- Relationship of F-actin distribution to development of polar shape in human polymorphonuclear neutrophils.The Journal of cell biology · 1992Article
- Insoluble immune complex-stimulated neutrophil leukotriene B4 production is dependent on Fc gamma RII and Fc gamma RIII and independent of pertussis toxin-sensitive signal transduction pathways.The American journal of pathology · 1992Article
- Control of actin polymerization in live and permeabilized fibroblasts.The Journal of cell biology · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nitrobenzoxadiazole-phallacidin in combination with quantitative fluorescent microscopy have been used to measure F-actin concentrations in human polymorphonuclear leukocytes (PMN) as they adhere to a plastic surface. Like stimulation with chemoattractants, adherence is associated with a twofold rise in F-actin content. However unlike the rapid rise in F-actin induced by chemoattractants which peaks within 30 s, actin assembly induced by adherence is slower, maximum F-actin values not being observed until 10 min. Furthermore the rise in F-actin induced by adherence is persistent, remaining constant over 60 min while F-actin returns to near basal levels after 20 min exposure to chemoattractant. The combination of adherence (5 min) followed by chemoattractant (FMLP 5 x 10(-8) M for 40 s) resulted in an additive rise in F-actin content to greater than threefold over unstimulated values. Unlike chemoattractant induced actin assembly, adherence-associated PMN actin polymerization was not inhibited by pertussis toxin, but was markedly reduced by lowering extracellular Ca2+. Fluorescent micrographs of adherent PMN stained with nitrobenzoxadiazole-phallacidin revealed F-actin in the lamellipodia and in small foci on the adherent surface. These findings suggest that the transduction mechanisms by which adherence induces PMN actin polymerization differ from those used by chemoattractant receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.