ArticleIUCrJ2014
Femtosecond X-ray diffraction from two-dimensional protein crystals.
Article in IUCrJ, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 84 citations in OpenAlex.
- Macromolecular crystallography and biology at the Linac Coherent Light Source.Journal of synchrotron radiation · 2025Article
- Novel fixed-target serial crystallography flip-holder for macromolecular crystallography beamlines at synchrotron radiation sources.Journal of synchrotron radiation · 2025Article
- Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering.Frontiers in chemistry · 2022Review
- Plug-and-play polymer microfluidic chips for hydrated, room temperature, fixed-target serial crystallography.Lab on a chip · 2021Article
- Electric Triggering for Enhanced Control of Droplet Generation.Analytical chemistry · 2019Article
- Nylon mesh-based sample holder for fixed-target serial femtosecond crystallography.Scientific reports · 2019Article
- Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene.Nature communications · 2018Article
- Femtosecond X-ray diffraction from an aerosolized beam of protein nanocrystals.Journal of applied crystallography · 2018Article
- Article
- Perspective: Opportunities for ultrafast science at SwissFEL.Structural dynamics (Melville, N.Y.) · 2017Article
- Perspective: A toolbox for protein structure determination in physiological environment through oriented, 2D ordered, site specific immobilization.Structural dynamics (Melville, N.Y.) · 2017Article
- XFELs for structure and dynamics in biology.IUCrJ · 2017Review
- Serial femtosecond crystallography opens new avenues for Structural Biology.Protein and peptide letters · 2016Article
- Accurate determination of segmented X-ray detector geometry.Optics express · 2015Article
- Metalloprotein structures at ambient conditions and in real-time: biological crystallography and spectroscopy using X-ray free electron lasers.Current opinion in structural biology · 2015Review
- A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions.Acta crystallographica. Section D, Biological crystallography · 2015Article
- Data collection strategies for time-resolved X-ray free-electron laser diffraction, and 2-color methods.Structural dynamics (Melville, N.Y.) · 2015Article
- Time-resolved structural studies with serial crystallography: A new light on retinal proteins.Structural dynamics (Melville, N.Y.) · 2015Article
- Review
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Authors and funding
25 authors at 6 institutions in 3 countries.
Funding
Abstract
X-ray diffraction patterns from two-dimensional (2-D) protein crystals obtained using femtosecond X-ray pulses from an X-ray free-electron laser (XFEL) are presented. To date, it has not been possible to acquire transmission X-ray diffraction patterns from individual 2-D protein crystals due to radiation damage. However, the intense and ultrafast pulses generated by an XFEL permit a new method of collecting diffraction data before the sample is destroyed. Utilizing a diffract-before-destroy approach at the Linac Coherent Light Source, Bragg diffraction was acquired to better than 8.5 Å resolution for two different 2-D protein crystal samples each less than 10 nm thick and maintained at room temperature. These proof-of-principle results show promise for structural analysis of both soluble and membrane proteins arranged as 2-D crystals without requiring cryogenic conditions or the formation of three-dimensional crystals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.