Evidence map›Paper›PMID 25075260›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2013

Infrared neural stimulation in the cochlea.

Claus-Peter Richter, Suhrud Rajguru, Mark Bendett

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. On the Horizon: Cochlear Implant Technology.Otolaryngologic clinics of North America · 2015
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Claus-Peter RichterDepartment of Otolaryngology, Northwestern University, 303 E. Chicago Ave, Searle 12-561, Chicago, IL 60611, USA ; Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Tech E310, Evanston, IL 60208, USA ; The Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA.
Suhrud RajguruDepartment of Biomedical Engineering, University of Miami, Miami FL 33146, USA ; Department of Otolaryngology, University of Miami, Miami FL 33136, USA.
Mark BendettLockheed Martin Aculight, 22121 20th Ave SE, Bothell WA, USA.

Funding

Understanding the Benefits of Infrared Nerve Stimulators for Neural InterfacesR01DC011855 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RICHTER, CLAUS-PETER · 2012 to 2016
$2.4M
Infrared Photoactivation of Inner-Ear Hair CellsR01DC011481 · NIDCD · MARINE BIOLOGICAL LABORATORY · PI RABBITT, RICHARD D · 2011 to 2013
$984k
NIDCD NIH HHS R01 DC011481NIDCD NIH HHS R01 DC011855
6 · The paper itself

Abstract

The application of photonics to manipulate and stimulate neurons and to study neural networks has gained momentum over the last decade. Two general methods have been used: the genetic expression of light or temperature sensitive ion channels in the plasma membrane of neurons (Optogenetics and Thermogenetics) and the direct stimulation of neurons using infrared radiation (Infrared Neural Stimulation, INS). Both approaches have their strengths and challenges, which are well understood with a profound understanding of the light tissue interaction(s). This paper compares the opportunities of the methods for the use in cochlear prostheses. Ample data are already available on the stimulation of the cochlea with INS. The data show that the stimulation is selective, feasible at rates that would be sufficient to encode acoustic information and may be beneficial over conventional pulsed electrical stimulation. A third approach, using lasers in stress confinement to generate pressure waves and to stimulate the functional cochlea mechanically will also be discussed.

Indexed as

cochlear implantsinfrared neural stimulationoptical stimulationoptogeneticsthermogenetics

Identifiers

PMID25075260
PMCPMC4112112

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.