ArticleJournal of innovative optical health sciences2014
Application of Multiphoton Microscopy in Dermatological Studies: a Mini-Review.
Article in Journal of innovative optical health sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Noninvasive Multimodal Imaging and Its Role in Diagnosing Skin Lesions in Dermatology: A Systematic Review and Meta-Analysis.American journal of clinical dermatology · 2025Pooled it
- Imaging Active Drug Transport in Viable Human Skin: A Functional ex vivo Skin Model for Mechanistic and Regulatory Applications.Skin pharmacology and physiology · 2026Article
- Artificial intelligence in atopic dermatitis: Current applications and future perspectives.Chinese medical journal · 2026Review
- In vivo human skin imaging: Distinguishing cellular and fibrillar components with fluorescence lifetime microscopy.The Journal of investigative dermatology · 2026Article
- Live imaging of skin immunity using two-photon microscopy: a short review.Inflammation and regeneration · 2026Review
- Advanced Skin Imaging Techniques for Patients with Skin of Color: Clinical and Technological Insights.Dermatology practical & conceptual · 2025Review
- Label-free visualization and quantitative analysis of Far UV-C skin safety with dynamic optical coherence tomography with subcellular resolution.Biomedical optics express · 2025Article
- Four-modal device comprising optical coherence tomography, photoacoustic tomography, ultrasound, and Raman spectroscopy developed for in vivo skin lesion assessment.Biomedical optics express · 2025Article
- Skin layer-specific spatiotemporal assessment of micrometabolism during wound angiogenesis.Communications biology · 2024Article
- Handheld multiphoton and pinhole-free reflectance confocal microscopy enables noninvasive, real-time cross-sectional imaging in skin.Scientific reports · 2024Article
- Seeing the unseen: The role of bioimaging techniques for the diagnostic interventions in intervertebral disc degeneration.Bone reports · 2024Review
- Non-invasive 3D imaging of human melanocytic lesions by combined ultrasound and photoacoustic tomography: a pilot study.Scientific reports · 2024Article
- A Dual-Modality Imaging Method Based on Polarimetry and Second Harmonic Generation for Characterization and Evaluation of Skin Tissue Structures.International journal of molecular sciences · 2023Article
- Label-Free Imaging and Histo-Optical Evaluation of Head and Neck Cancers with Multiphoton Autofluorescence Microscopy.Cancers · 2023Article
- Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts.International journal of molecular sciences · 2023Review
- In vivo multiphoton multiparametric 3D quantification of human skin aging on forearm and face.Scientific reports · 2022Article
- Real-time observation of neutrophil extracellular trap formation in the inflamed mouse brain via two-photon intravital imaging.Laboratory animal research · 2022Review
- Non-invasive longitudinal imaging of VEGF-induced microvascular alterations in skin wounds.Theranostics · 2022Article
- Non-Invasive Skin Imaging Assessment of Human Stress During Head-Down Bed Rest Using a Portable Handheld Two-Photon Microscope.Frontiers in physiology · 2022Article
- Long-Term Imaging of Wound Angiogenesis with Large Scale Optoacoustic Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
This review summarizes the historical and more recent developments of multiphoton microscopy, as applied to dermatology. Multiphoton microscopy offers several advantages over competing microscopy techniques: there is an inherent axial sectioning, penetration depths that compete well with confocal microscopy on account of the use of near-infrared light, and many two-photon contrast mechanisms, such as second-harmonic generation, have no analogue in one-photon microscopy. While the penetration depths of photons into tissue are typically limited on the order of hundreds of microns, this is of less concern in dermatology, as the skin is thin and readily accessible. As a result, multiphoton microscopy in dermatology has generated a great deal of interest, much of which is summarized here. The review covers the interaction of light and tissue, as well as the various considerations that must be made when designing an instrument. The state of multiphoton microscopy in imaging skin cancer and various other diseases is also discussed, along with the investigation of aging and regeneration phenomena, and finally, the use of multiphoton microscopy to analyze the transdermal transport of drugs, cosmetics and other agents is summarized. The review concludes with a look at potential future research directions, especially those that are necessary to push these techniques into widespread clinical acceptance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.