Evidence map›Paper›PMID 25075210›Full record

ArticleInfectious agents and cancer2014

MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives.

Carolina Mm Amaral, Katerina Cetkovská, Ana Pad Gurgel, Marcus V Cardoso, Bárbara S Chagas, Sérgio Sl Paiva Júnior, Rita de Cássia Pereira de Lima, Jacinto C Silva-Neto, Luiz Af Silva, Maria Tc Muniz and 2 more

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In one paragraph

Article in Infectious agents and cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Carolina Mm AmaralLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Universidade Federal de Pernambuco, Pernambuco, Brazil.
Katerina CetkovskáDepartment of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Ana Pad GurgelLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Universidade Federal de Pernambuco, Pernambuco, Brazil.
Marcus V CardosoLaboratory of Human Molecular Genetics, Department of Genetics, Universidade Federal de Pernambuco, Pernambuco, Brazil.
Bárbara S ChagasLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Universidade Federal de Pernambuco, Pernambuco, Brazil.
Sérgio Sl Paiva JúniorLaboratory of Human Molecular Genetics, Department of Genetics, Universidade Federal de Pernambuco, Pernambuco, Brazil.
Rita de Cássia Pereira de LimaLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Universidade Federal de Pernambuco, Pernambuco, Brazil.
Jacinto C Silva-NetoMolecular and Cytological Research Laboratory, Department of Histology, Universidade Federal de Pernambuco, Pernambuco, Brazil.
Luiz Af SilvaInstitute of Biological Sciences and Health, Federal University of Alagoas, Alagoas, Brazil.
Maria Tc MunizLaboratory of Molecular Biology of Center of Pediatric Oncohaematological, University of Pernambuco, Pernambuco, Brazil.
Valdir Q BalbinoLaboratory of Human Molecular Genetics, Department of Genetics, Universidade Federal de Pernambuco, Pernambuco, Brazil.
Antonio C FreitasLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Universidade Federal de Pernambuco, Pernambuco, Brazil.
Universidade Federal de Pernambuco · BRMasaryk University · CZUniversidade de Pernambuco · BRUniversidade Federal de Alagoas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region of MDM2 gene leads to increased expression resulting in higher levels of MDM2 protein. This event increases the attenuation of the p53 pathway. Polymorphisms in this gene can interfere in the regulation of cellular proliferation. We evaluated whether MDM2 SNP309 (rs2278744) associated or not with the use of oral contraceptive can heighten susceptibility to development of cervical lesions in women HPV infected.

methodsMDM2 SNP309 (rs2278744) was genotyped in a total of 287 patients using the PCR-RFLP technique. The results were analyzed by UNPHASED v.3.121 and SNPStats programs.

resultsThe three groups (SIL, LSIL and HSIL) showed no significant differences in either genotype or allelic frequencies for MDM2 polymorphisms, except when HSIL was compared with LSIL (p = 0.037; OR = 1.81). Furthermore, in the analysis of contraceptives, a significant association was found between the use of contraceptives and the MDM2 variant in the development of high-grade cervical lesions for the TG genotype (p = 0.019; OR = 2.21) when HSIL was compared with control. When HSIL was compared with LSIL (p = 0.006; OR = 2.27).

conclusionThe results of this study suggest that MDM2 SNP309 might be a good marker for assessing the progression of LSIL to HSIL. In addition, they also show that oral contraceptives alone, did not have any effect on the progression or development of cervical lesions. However, they may act synergistically with MDM2 SNP309 (rs2278744) and HPV infection in the development of cervical lesions.

Indexed as

Cervical cancerHPVMDM2Oral contraceptives

Identifiers

PMID25075210
PMCPMC4113664
OpenAlexW2109180414

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.