ReviewVascular health and risk management2014
Lower extremity amputation in peripheral artery disease: improving patient outcomes.
Review in Vascular health and risk management, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03722797 (Metabolic Cost and Physical Activity in Sedentary Adults With a Unilateral Transtibial Amputation as Compared to Controls), which is not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolic Cost and Physical Activity in Sedentary Adults With a Unilateral Transtibial Amputation as Compared to Controls
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Omega-3 Polyunsaturated Fatty Acids are not associated with Peripheral Artery Disease in a Meta-Analysis from the Multi-Ethnic Study of Atherosclerosis and Atherosclerosis Risk in Communities Study Cohorts.The Journal of nutrition · 2024Pooled it
- Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- BAlloon versus Stenting in severe Ischaemia of the Leg-3 (BASIL-3): study protocol for a randomised controlled trial.Trials · 2017Trial
- Deep-learning-based diagnostic models for transcutaneous oxygen pressure-defined peripheral arterial disease and lower extremity wound healing in patients with diabetic foot.BMC medical informatics and decision making · 2026Article
- Genome-Wide Association Study of Genetic Variants Associated with Lower Extremity Amputation Risk in Peripheral Artery Disease.International journal of molecular sciences · 2026Article
- Implicit Bias and Recognition of Biases Among Vascular Surgeons.The Journal of surgical research · 2026Article
- Article
- A narrative review of imaging misallocation in peripheral artery disease: a value-based medicine perspective.Cardiovascular diagnosis and therapy · 2025Review
- Risk factors of major lower limb amputation in symptomatic peripheral artery disease: a retrospective cohort study.Future science OA · 2025Article
- Etiologies and Trends in Extremity Amputations: A Ten-Year Single-Center Experience.Healthcare (Basel, Switzerland) · 2025Article
- Development of a novel protocol for processing fluorescent microspheres used in quantifying tissue perfusion.Sensing and Bio-Sensing Research · 2025Article
- AMPREDICT MoRe: Predicting Mortality and Re-amputation Risk after Dysvascular Amputation.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2025Article
- Socioeconomic and ethnic disparities in major lower limb amputation related to peripheral arterial disease in England.BJS open · 2025Article
- Ex Vivo Human Tissue Functions as a Testing Platform for the Evaluation of a Nerve-Specific Fluorophore.Molecular imaging and biology · 2025Article
- The misleading terminology of minor amputation of the lower limb.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Development of an Audiovisual Tool on Peripheral Arterial Disease and Preliminary Suitability Assessment.Portuguese journal of public health · 2024Article
- The Use of Clot Strength as a Predictor of Thrombosis in Peripheral Artery Disease.Annals of vascular surgery · 2024Observational
- Elevated Shear Stress Modulates Heterogenous Cellular Subpopulations to Induce Vascular Remodeling.Tissue engineering. Part A · 2024Article
- Identification of CD141Stem cell research & therapy · 2024Article
- Investigating Unconscious Race Bias and Bias Awareness Among Vascular Surgeons.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral artery disease affects over eight million Americans and is associated with an increased risk of mortality, cardiovascular disease, functional limitation, and limb loss. In its most severe form, critical limb ischemia, patients are often treated with lower extremity (LE) amputation (LEA), although the overall incidence of LEA is declining. In the US, there is significant geographic variation in the performing of major LEA. The rate of death after major LEA in the US is approximately 48% at 1 year and 71% at 3 years. Despite this significant morbidity and mortality, the use of diagnostic testing (both noninvasive and invasive testing) in the year prior to LEA is low and varies based on patient, provider, and regional factors. In this review we discuss the significance of LEA and methods to reduce its occurrence. These methods include improved recognition of the risk factors for LEA by clinicians and patients, strong advocacy for noninvasive and/or invasive imaging prior to LEA, improved endovascular revascularization techniques, and novel therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.