ReviewNeuropsychiatric disease and treatment2014
Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia.
Review in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Selective 5HT3 antagonists and sensory processing: a systematic review.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Neurophysiology of Sleep-Deprivation Part 1: Effects of Sleep-Deprivation on Event-Related Potentials (ERPs)-Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Modulatory effects of transcranial direct current stimulation on sensory gating in Fibromyalgia Syndrome.Frontiers in psychology · 2025Article
- Sensory Inhibition and Tinnitus: Measurement of Auditory Gating.Seminars in hearing · 2024Review
- It's in the Timing: Reduced Temporal Precision in Neural Activity of Schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Neurophysiology in psychosis: The quest for disease biomarkers.Translational psychiatry · 2022Review
- A systematic review of the neural correlates of multisensory integration in schizophrenia.Schizophrenia research. Cognition · 2022Article
- Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.Frontiers in psychiatry · 2020Review
- Neurophysiological Biomarkers in Schizophrenia-P50, Mismatch Negativity, and TMS-EMG and TMS-EEG.Frontiers in psychiatry · 2020Review
- Normal hearing young adults with mild tinnitus: Reduced inhibition as measured through sensory gating.Audiology research · 2018Article
- Differential modulation of the auditory steady state response and inhibitory gating by chloral hydrate anesthesia.Scientific reports · 2018Article
- Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders.Schizophrenia bulletin · 2017Article
- N100 as a generic cortical electrophysiological marker based on decomposition of TMS-evoked potentials across five anatomic locations.Experimental brain research · 2017Article
- The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia.Scientific reports · 2016Article
- Positive and Negative Symptoms in Schizophrenia Relate to Distinct Oscillatory Signatures of Sensory Gating.Frontiers in human neuroscience · 2016Article
- Beta/Gamma Oscillations and Event-Related Potentials Indicate Aberrant Multisensory Processing in Schizophrenia.Frontiers in psychology · 2016Article
- Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Different P50 sensory gating measures reflect different cognitive dysfunctions in schizophrenia.Schizophrenia research. Cognition · 2015Article
- Fetal programming of schizophrenia: select mechanisms.Neuroscience and biobehavioral reviews · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory gating disturbances in schizophrenia are often described as an inability to filter redundant sensory stimuli that typically manifest as inability to gate neuronal responses related to the P50 wave, characterizing a decreased ability of the brain to inhibit various responses to insignificant stimuli. It implicates various deficits of perceptual and attentional functions, and this inability to inhibit, or "gate", irrelevant sensory inputs leads to sensory and information overload that also may result in neuronal hyperexcitability related to disturbances of habituation mechanisms. These findings seem to be particularly important in the context of modern electrophysiological and neuroimaging data suggesting that the filtering deficits in schizophrenia are likely related to deficits in the integrity of connections between various brain areas. As a consequence, this brain disintegration produces disconnection of information, disrupted binding, and disintegration of consciousness that in terms of modern neuroscience could connect original Bleuler's concept of "split mind" with research of neural information integration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.