Cancer stem cells converted from pluripotent stem cells and the cancerous niche.

T Kasai, L Chen, Az Mizutani, T Kudoh, H Murakami, L Fu, M Seno

Abstract readReview

In one paragraph

Review in Journal of stem cells & regenerative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it

0cells of the map it votes in

12citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

Advances in Genetic Reprogramming: Prospects from Developmental Biology to Regenerative Medicine.Current medicinal chemistry · 2024
Review
Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs.NPJ Regenerative medicine · 2023
Article
Promotion of tumor progression and cancer stemness by MUC15 in thyroid cancer via the GPCR/ERK and integrin-FAK signaling pathways.Oncogenesis · 2018
Article
Induction of cells with prostate cancer stem-like properties from mouse induced pluripotent stem cells via conditioned medium.American journal of cancer research · 2018
Article
Murine melanoma cells incomplete reprogramming using non-viral vector.Cell proliferation · 2017
Article
APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases.Experimental biology and medicine (Maywood, N.J.) · 2017
Review
Cancer cell reprogramming to identify the genes competent for generating liver cancer stem cells.Inflammation and regeneration · 2017
Review
HLA-E inhibitor enhances the killing of neuroblastoma stem cells by co-cultured dendritic cells and cytokine-induced killer cells loaded with membrane-based microparticles.American journal of cancer research · 2017
Article
(Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression.Cancer research · 2016
Article
A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm).American journal of cancer research · 2016
Article
Advances and Challenges on Cancer Cells Reprogramming Using Induced Pluripotent Stem Cells Technologies.Journal of Cancer · 2016
Review
The role of piRNA and its potential clinical implications in cancer.Epigenomics · 2015
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

T KasaiDepartment of Biotechnology, Graduate School of Natural Science and Technology , Okayama University, Okayama, Japan.

L ChenDepartment of Pathology, Tianjin Central Hospital of Gynecology Obstetrics , Tianjin, China.

Az MizutaniDepartment of Biotechnology, Graduate School of Natural Science and Technology , Okayama University, Okayama, Japan.

T KudohDepartment of Biotechnology, Graduate School of Natural Science and Technology , Okayama University, Okayama, Japan.

H MurakamiDepartment of Biotechnology, Graduate School of Natural Science and Technology , Okayama University, Okayama, Japan.

L FuDepartment of Breast Cancer Pathology and Research laboratory of Cancer Hospital , Tianjin Medical University, Tianjin, China.

M SenoDepartment of Biotechnology, Graduate School of Natural Science and Technology , Okayama University, Okayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nowadays, the cancer stem cells are considered to be significantly responsible for growth, metastasis, invasion and recurrence of all cancer. Cancer stem cells are typically characterized by continuous proliferation and self-renewal as well as by differentiation potential, while stem cells are considered to differentiate into tissue- specific phenotype of mature cells under the influence of micro-environment. Cancer stem cells should be traced to the stem cells under the influence of a micro-environment, which induces malignant tumors. In this review, we propose this micro-environment as a 'cancerous niche' and discuss its importance on the formation and maintenance of cancer stem cells with the recent experimental results to establish cancer stem cell models from induced pluripotent stem cells. These models of cancer stem cell will provide the great advantages in cancer research and its therapeutic applications in the future.

Identifiers

PMID25075155

PMCPMC4112272

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.