ArticleSchizophrenia bulletin2015
Sleep spindles are related to schizotypal personality traits and thalamic glutamine/glutamate in healthy subjects.
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 41 citations in OpenAlex.
- Multimodal evidence of mediodorsal thalamus-prefrontal circuit dysfunctions in clinical high-risk for psychosis: findings from a combined 7T fMRI, MRSI and sleep Hd-EEG study.Molecular psychiatry · 2025Article
- A comparative analysis of sleep spindle characteristics of sleep-disordered patients and normal subjects.Frontiers in neuroscience · 2023Article
- Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable GclmMolecular psychiatry · 2022Article
- Nutrition, Sleep, and Exercise as Healthy Behaviors in Schizotypy: A Scoping Review.Behavioral sciences (Basel, Switzerland) · 2022Article
- Effects of Alcohol Extracts FromFrontiers in nutrition · 2022Article
- Nonrapid eye movement sleep characteristics and relations with motor, memory, and cognitive ability from infancy to preadolescence.Developmental psychobiology · 2021Review
- Neuromodulation of sleep rhythms in schizophrenia: Towards the rational design of non-invasive brain stimulation.Schizophrenia research · 2020Review
- Neurophysiological substrates of configural face perception in schizotypy.Schizophrenia research · 2020Article
- Increased Thalamocortical Connectivity in Schizophrenia Correlates With Sleep Spindle Deficits: Evidence for a Common Pathophysiology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.Annual review of clinical psychology · 2019Review
- Insomnia and intellect mask the positive link between schizotypal traits and creativity.PeerJ · 2018Article
- Corticolimbic hyper-response to emotion and glutamatergic function in people with high schizotypy: a multimodal fMRI-MRS study.Translational psychiatry · 2017Article
- Fast sleep spindle reduction in schizophrenia and healthy first-degree relatives: association with impaired cognitive function and potential intermediate phenotype.European archives of psychiatry and clinical neuroscience · 2017Article
- Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?Biological psychiatry · 2016Review
- Sleep Spindle Deficit in Schizophrenia: Contextualization of Recent Findings.Current psychiatry reports · 2016Review
- Perspective-taking abilities in the balance between autism tendencies and psychosis proneness.Proceedings. Biological sciences · 2015Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchizophrenia is a severe mental disorder affecting approximately 1% of the worldwide population. Yet, schizophrenia-like experiences (schizotypy) are very common in the healthy population, indicating a continuum between normal mental functioning and the psychosis found in schizophrenic patients. A continuum between schizotypy and schizophrenia would be supported if they share the same neurobiological origin. Two such neurobiological markers of schizophrenia are: (1) a reduction of sleep spindles (12-15 Hz oscillations during nonrapid eye movement sleep), likely reflecting deficits in thalamo-cortical circuits and (2) increased glutamine and glutamate (Glx) levels in the thalamus. Thus, this study aimed to investigate whether sleep spindles and Glx levels are related to schizotypal personality traits in healthy subjects.
methodsTwenty young male subjects underwent 2 all-night sleep electroencephalography recordings (128 electrodes). Sleep spindles were detected automatically. After those 2 nights, thalamic Glx levels were measured by magnetic resonance spectroscopy. Subjects completed a magical ideation scale to assess schizotypy.
resultsSleep spindle density was negatively correlated with magical ideation (r = -.64, P < .01) and thalamic Glx levels (r = -.70, P < .005). No correlation was found between Glx levels in the thalamus and magical ideation (r = .12, P > .1).
conclusionsThe common relationship of sleep spindle density with schizotypy and thalamic Glx levels indicates a neurobiological overlap between nonclinical schizotypy and schizophrenia. Thus, sleep spindle density and magical ideation may reflect the anatomy and efficiency of the thalamo-cortical system that shows pronounced impairment in patients with schizophrenia.
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