ArticleInvestigative ophthalmology & visual science2014
Choroidal and retinal thickening in severe preeclampsia.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Decoding systemic vascular health and hypertensive disorders in pregnancy through retinal imaging and Visionary AI.Nature biotechnology · 2026Article
- Assessing Retinal Thickness and Associations with Cognitive Function in Women with History of Preeclampsia.Eye and brain · 2026Article
- Relationship between proteinuria and changes in antepartum and postpartum choroidal thickness in patients with pre-eclampsia.Scientific reports · 2024Article
- Preeclampsia and the Retina.Current hypertension reports · 2024Review
- Quantitative analysis of choroidal morphology in preeclampsia during pregnancy according to retinal change.Scientific reports · 2023Article
- Subfoveal Choroidal Thickness and Associated Changes of Angiogenic Factors in Women with Severe Preeclampsia.American journal of perinatology · 2021Article
- Relationship between proteinuria and optical coherence tomographic features of the chorioretina in patients with pre-eclampsia.PloS one · 2021Article
- Article
- Plane-Wave Ultrasound Doppler of the Eye in Preeclampsia.Translational vision science & technology · 2020Article
- Observational
- Serous retinal detachment in preeclampsia and malignant hypertension.Eye (London, England) · 2019Article
- Choroidal thickness in preeclampsia measured by spectral-domain optical coherence tomography.International ophthalmology · 2019Article
- Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
- Choroidal thickness in pregnant women: a cross-sectional study.International journal of ophthalmology · 2016Article
- Evaluation of Choroidal Thickness and Volume during the Third Trimester of Pregnancy using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study.Journal of clinical and diagnostic research : JCDR · 2015Article
- Exudative Retinal Detachment and Ciliochoroidal Effusion in Preeclampsia.Journal of vitreoretinal diseasesArticle
- Assessment of Choroidal Structure in Third-Trimester Pregnant Women.Journal of current ophthalmologyArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo compare choroidal thickness and retinal macular volume (RMV) among three groups of women: severe preeclampsia postpartum, normotensive postpartum, and normotensive nongravid. While visual disturbances often accompany severe preeclampsia, the underlying choroidal and retinal changes responsible for these symptoms have not been described.
methodsThis case-control study was based on 15 severe preeclampsia cases and 15 ethnicity- and parity-matched normotensive controls recruited during the postpartum hospital stay. A reference group of 19 age-matched, nongravid, normotensive women was also studied. Choroidal thickness and RMV were measured by using enhanced depth imaging spectral-domain optical coherence tomography. Two retinal specialists, one of whom was masked to the case-control status, reviewed all images.
resultsSevere preeclampsia cases demonstrated greater mean choroidal thickness (425 ± 90 μm vs. 354 ± 140 μm; P = 0.021) and RMV (9.0 ± 0.4 mm(3) vs. 8.7 ± 0.5 mm(3); P = 0.006) than controls. In contrast, control and reference groups were similar with respect to choroidal thickness (354 ± 140 μm vs. 363 ± 82 μm; P = 0.764) and RMV (8.7 ± 0.5 mm(3) vs. 8.8 ± 0.4 mm(3); P = 0.870). Follow-up imaging of two severe preeclampsia cases within 3 months of delivery revealed decreasing choroidal thickness.
conclusionsOur results demonstrate subclinical retinal and choroidal thickening in the setting of severe preeclampsia. This is the likely source of its associated visual phenomena and may reflect rising levels of vascular endothelial growth factor. Retinal and choroidal markers could serve as novel predictive markers of severe preeclampsia.
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