ArticleBMC infectious diseases2014
Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 136 citations in OpenAlex.
- Do Polymicrobial Intra-Abdominal Infections Have Worse Outcomes than Monomicrobial Intra-Abdominal Infections?Surgical infections · 2016Trial
- Clinical characteristics and prognostic factors of severe intra-abdominal infection due to gastrointestinal perforation: a retrospective cohort study.BMC surgery · 2026Article
- Machine learning for prognostic assessment in elderly patients with gastroduodenal perforation.BMC surgery · 2026Article
- Epidemiology and outcome of intra-abdominal infections in intensive care unit in Italy from the Italian Register of complicated Intra-abdominal InfectionS-the IRIS study: a prospective observational nationwide study.Journal of anesthesia, analgesia and critical care · 2026Article
- Prognostic impact ofAnnals of intensive care · 2026Article
- Trends in mortality, pathogen distribution, and antimicrobial resistance of peritoneal and intra-abdominal infections from 1990 to 2021: a cross-sectional analysis of the MICROBE database.International journal of surgery (London, England) · 2025Article
- Optimizing postoperative infection control strategies in gastrointestinal surgeryWorld journal of gastrointestinal surgery · 2025Article
- Prognostic value of neutrophil-to-lymphocyte ratio in septic patients with liver cirrhosis: a cohort study.BMC gastroenterology · 2025Article
- [Calculated anti-infective agent treatment on the intensive care unit 24/7/365].Die Anaesthesiologie · 2025Article
- Direct Peritoneal Resuscitation in Critically Ill Patients with an Open Abdomen is Associated with Increased Risk of Intraperitoneal Fungal Infections.Surgical infections · 2025Article
- The association of sepsis bundle compliance with mortality in patients with ICU-acquired sepsis: a cohort study.BMC infectious diseases · 2025Article
- Diagnostic utility of IL-18 plasma levels in distinguishing abdominal from non-abdominal sepsis.Frontiers in immunology · 2025Article
- Acute gastric volvulus combined with pneumatosis coli rupture misdiagnosed as gastric volvulus with perforation: A case report.World journal of gastrointestinal surgery · 2024Article
- Infectious Foci, Comorbidities and Its Influence on the Outcomes of Septic Critically Ill Patients.Microorganisms · 2024Article
- Empirical antifungal therapy for health care-associated intra-abdominal infection: a retrospective, multicentre and comparative study.Annals of intensive care · 2024Article
- Utility of paired plasma and drainage fluid mNGS in diagnosing acute intra-abdominal infections with sepsis.BMC infectious diseases · 2024Article
- 11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis.Frontiers in bioengineering and biotechnology · 2024Article
- Optimized Treatment of Nosocomial Peritonitis.Antibiotics (Basel, Switzerland) · 2023Review
- Combination of serum and peritoneal 1.3-beta-D-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study.Critical care (London, England) · 2023Article
- Predictive nomogram for in-hospital mortality among older patients with intra-abdominal sepsis incorporating skeletal muscle mass.Aging clinical and experimental research · 2023Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbdominal infections are frequent causes of sepsis and septic shock in the intensive care unit (ICU) and are associated with adverse outcomes. We analyzed the characteristics, treatments and outcome of ICU patients with abdominal infections using data extracted from a one-day point prevalence study, the Extended Prevalence of Infection in the ICU (EPIC) II.
methodsEPIC II included 13,796 adult patients from 1,265 ICUs in 75 countries. Infection was defined using the International Sepsis Forum criteria. Microbiological analyses were performed locally. Participating ICUs provided patient follow-up until hospital discharge or for 60 days.
resultsOf the 7,087 infected patients, 1,392 (19.6%) had an abdominal infection on the study day (60% male, mean age 62 ± 16 years, SAPS II score 39 ± 16, SOFA score 7.6 ± 4.6). Microbiological cultures were positive in 931 (67%) patients, most commonly Gram-negative bacteria (48.0%). Antibiotics were administered to 1366 (98.1%) patients. Patients who had been in the ICU for ≤ 2 days prior to the study day had more Escherichia coli, methicillin-sensitive Staphylococcus aureus and anaerobic isolates, and fewer enterococci than patients who had been in the ICU longer. ICU and hospital mortality rates were 29.4% and 36.3%, respectively. ICU mortality was higher in patients with abdominal infections than in those with other infections (29.4% vs. 24.4%, p < 0.001). In multivariable analysis, hematological malignancy, mechanical ventilation, cirrhosis, need for renal replacement therapy and SAPS II score were independently associated with increased mortality.
conclusionsThe characteristics, microbiology and antibiotic treatment of abdominal infections in critically ill patients are diverse. Mortality in patients with isolated abdominal infections was higher than in those who had other infections.
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